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International Spread of Multidrug-Resistant Campylobacter coli in Men Who Have Sex With Men in Washington State and Québec, 2015–2018
- Source :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- Background Campylobacter species are among the most common causes of enteric bacterial infections worldwide. Men who have sex with men (MSM) are at increased risk for sexually transmitted enteric infections, including globally distributed strains of multidrug-resistant Shigella species. Methods This was a retrospective study of MSM-associated Campylobacter in Seattle, Washington and Montréal, Québec with phenotypic antimicrobial resistance profiles and whole genome sequencing (WGS). Results We report the isolation of 2 clonal lineages of multidrug-resistant Campylobacter coli from MSM in Seattle and Montréal. WGS revealed nearly identical strains obtained from the 2 regions over a 4-year period. Comparison with the National Center for Biotechnology Information’s Pathogen Detection database revealed extensive Campylobacter species clusters carrying multiple drug resistance genes that segregated with these isolates. Examination of the genetic basis of antimicrobial resistance revealed multiple macrolide resistance determinants including a novel ribosomal RNA methyltransferase situated in a CRISPR (clustered regularly interspaced short palindromic repeats) array locus in a C. coli isolate. Conclusions As previously reported for Shigella, specific multidrug-resistant strains of Campylobacter are circulating by sexual transmission in MSM populations across diverse geographic locations, suggesting a need to incorporate sexual behavior in the investigation of clusters of foodborne pathogens revealed by WGS data.<br />We show defined clonal lineages of likely sexually transmitted Campylobacter species associated with spread in men who have sex with men between Seattle and Montréal. We also report the first CRISPR-acquired antibiotic resistance gene in a clinical isolate.
- Subjects :
- Male
Washington
0301 basic medicine
Microbiology (medical)
Washington State
Sexual transmission
030106 microbiology
Campylobacter coli
Microbial Sensitivity Tests
medicine.disease_cause
Men who have sex with men
Sexual and Gender Minorities
03 medical and health sciences
Antibiotic resistance
Campylobacter Infections
Drug Resistance, Bacterial
Humans
Medicine
Shigella
MSM
antimicrobial resistance
Homosexuality, Male
Articles and Commentaries
Retrospective Studies
Genetics
biology
business.industry
Campylobacter
Quebec
Ribosomal RNA
biology.organism_classification
Anti-Bacterial Agents
Québec
Multiple drug resistance
AcademicSubjects/MED00290
030104 developmental biology
Infectious Diseases
Macrolides
business
Subjects
Details
- ISSN :
- 15376591 and 10584838
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Clinical Infectious Diseases
- Accession number :
- edsair.doi.dedup.....c058ac0649f2978a83cc555b383758c7