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Stability and properties of Z-DNA containing artificial nucleobase 2′-O-methyl-8-methyl guanosine
- Source :
- Bioorganic & Medicinal Chemistry. 27:364-369
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- We synthesized several DNA oligonucleotides containing one or several 2'-O-methyl-8-methyl guanosine (m8Gm) and demonstrated that these oligonucleotides not only stabilize the Z-DNA with a wide range of sequences under low salt conditions but also possess high thermal stability. Using artificial nucleobase-containing oligonucleotides, we studied the interaction of the Zα domain with Z-DNA. Furthermore, we showed that the m8Gm-contained oligonucleotides allow to study the photochemical reaction of Z-DNA.
- Subjects :
- Circular dichroism
Ultraviolet Rays
Green Fluorescent Proteins
Clinical Biochemistry
Pharmaceutical Science
Guanosine
01 natural sciences
Biochemistry
Nucleobase
Z-DNA
chemistry.chemical_compound
Low salt
Drug Discovery
DNA, Z-Form
Transition Temperature
Thermal stability
Molecular Biology
010405 organic chemistry
Oligonucleotide
Organic Chemistry
Combinatorial chemistry
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Oligodeoxyribonucleotides
chemistry
Molecular Medicine
Oxidation-Reduction
DNA
Protein Binding
Subjects
Details
- ISSN :
- 09680896
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....c04372a8a22585831ed7f91a4addb6c1