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GLYCOSAMINOGLYCAN METABOLISM IN ATROPHIED SKIN FROM A PATIENT TREATED WITH LONG-TERM ADMINISTRATION OF CORTICOSTEROIDS
- Source :
- The Journal of Dermatology. 12:280-282
- Publication Year :
- 1985
- Publisher :
- Wiley, 1985.
-
Abstract
- Skin tissue and explant culture were used to investigate glycosaminoglycan (GAG) metabolism in the atrophied skin of a patient treated with long-term oral corticosteroids. Total GAGs per dry weight were almost the same in the atrophied and control skin. Hyaluronic acid was increased 1.5 times above the control values. Dermatan sulfate decreased to 3% of the total GAGs in the atrophied skin; in the controls dermatan sulfate content was 30%. In the skin explant culture experiment, the synthetic activity of dermatan sulfate in the atrophied skin was higher than in the controls. These results suggest that the synthesis of hyaluronic acid and dermatan sulfate in atrophied skin is modulated by corticosteroid, which causes thinning, fragile skin.
- Subjects :
- Adult
medicine.medical_specialty
medicine.drug_class
Dermatology
Dermatan sulfate
Glycosaminoglycan
chemistry.chemical_compound
Adrenal Cortex Hormones
Internal medicine
Hyaluronic acid
Humans
Medicine
Glycosaminoglycans
Skin
integumentary system
business.industry
General Medicine
Metabolism
carbohydrates (lipids)
Endocrinology
chemistry
Corticosteroid
Female
Glycosaminoglycan metabolism
Atrophy
business
Fragile skin
Explant culture
Subjects
Details
- ISSN :
- 03852407
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- The Journal of Dermatology
- Accession number :
- edsair.doi.dedup.....c03414af7fe182cde02e33247473e7a4