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A Retrospective Study of the Imaging and Pathological Features of Metaplastic Breast Carcinoma and Review of the Literature
- Source :
- Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
- Publication Year :
- 2019
- Publisher :
- International Scientific Information, Inc., 2019.
-
Abstract
- BACKGROUND Metaplastic breast cancer (MBC) is a rare type of breast cancer, characterized histologically by the presence of two or more malignant cell types (epithelial and mesenchymal). This retrospective study aimed to review the imaging and histological features of MBC, with a review of the literature. MATERIAL AND METHODS Nineteen patients with MBC (age range, 28-75 years; mean, 55 years) underwent review of their clinical records, histopathology, immunohistochemistry, and imaging findings, which included mammography, sonography, and magnetic resonance imaging (MRI) with T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and diffusion restriction determined by the apparent diffusion coefficient (ADC) and a time-intensity curve (TIC) for signal intensity. RESULTS The mammographic features of MBC were oval shaped (54.5%), with indistinct margin (45.5%), and high tumor density (72.7%), and on sonography, they were oval shaped (57.1%), with hypo-echogenic areas (85.8%). On MRI, MBC showed moderate hyper-intensity with a high signal intensity in the center of the tumor on T2WI (100%), an indistinct margin (75.0%), and rim enhancement (58.3%). Using a TIC, the early phase showed rapid enhancement, and the delay phase showed a signal plateau (91.7%). DWI showed diffusion restriction in all cases determined by the ADC. Immunohistochemistry showed negative expression of estrogen receptor (ER) (91.0%), progesterone receptor (PR) (81%), and HER2 (erbB-2) (80.0%). CONCLUSIONS Imaging features of MBC on mammography and ultrasound were benign. The use of T2WI MRI showed characteristic features of signal intensity using TIC curve and ADC analysis, which may support biopsy and histological analysis for definitive diagnosis.
- Subjects :
- Adult
China
medicine.medical_specialty
Biopsy
Contrast Media
Breast Neoplasms
Constriction, Pathologic
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Breast cancer
Clinical Research
medicine
Humans
Mammography
Effective diffusion coefficient
Breast
Aged
Retrospective Studies
Metaplasia
medicine.diagnostic_test
business.industry
Ultrasound
Magnetic resonance imaging
General Medicine
Middle Aged
Metaplastic Breast Carcinoma
medicine.disease
Immunohistochemistry
Magnetic Resonance Imaging
body regions
Diffusion Magnetic Resonance Imaging
030220 oncology & carcinogenesis
Female
Histopathology
Nuclear medicine
business
Subjects
Details
- ISSN :
- 16433750
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Medical Science Monitor
- Accession number :
- edsair.doi.dedup.....c0303c589157806a19837304d0ca361c