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Imbalance between nitric oxide and dopamine may underly aggression in acute neurological patients
- Source :
- Neurochemical research. 35(10)
- Publication Year :
- 2010
-
Abstract
- The neurochemical basis of aggressive behavior in humans is not fully understood. In this study we explored the relationship between aggressiveness (as measured by the Overt Aggression Scale), cognitive performance (as measured by the Mini Mental State Examination), and biochemical markers of dopamine neurotransmission (homovanillic acid, HVA) and nitric oxide synthesis (nitrite plus nitrate, NO x ) in cerebrospinal fluid from 70 patients with acute brain disorders, mainly brain infections. Aggressive behavior and cognitive performance showed an inverse correlation. NO x /HVA ratio was inversely correlated to aggressive behavior, and positively correlated to cognitive performance. A subanalysis with antipsychotic-naive patients confirmed those results. The balance between nitric oxide and dopamine could be related to the cognitive control of aggressive impulse.
- Subjects :
- Adult
Male
medicine.medical_specialty
Neurology
Dopamine
Nitric Oxide
Biochemistry
Nitric oxide
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Neurochemical
Cognition
Internal medicine
medicine
Humans
Neurochemistry
Mini–Mental State Examination
medicine.diagnostic_test
Aggression
Homovanillic acid
Homovanillic Acid
General Medicine
Endocrinology
chemistry
Acute Disease
Female
medicine.symptom
Nervous System Diseases
Psychology
Neuroscience
medicine.drug
Subjects
Details
- ISSN :
- 15736903
- Volume :
- 35
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Neurochemical research
- Accession number :
- edsair.doi.dedup.....c02db66bcafe865854e8a6c3a4b65c19