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Mineralocorticoid receptor associates with pro-inflammatory bias in the hippocampus of spontaneously hypertensive rats
- Source :
- CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET, Journal of Neuroendocrinology, 29(7)
- Publication Year :
- 2017
-
Abstract
- Damage observed in the hippocampus of the adult spontaneously hypertensive rat (SHR) resembles the neuropathology of mineralocorticoid-induced hypertension, supporting a similar endocrine dysfunction in both entities. In the present study, we tested the hypothesis that increased expression of the hippocampal mineralocorticoid receptor (MR) in SHR animals is associated with a prevalent expression of pro-inflammatory over anti-inflammatory factors. Accordingly, in the hippocampus, we measured mRNA expression and immunoreactivity of the MR and glucocorticoid receptor (GR) using a quantitative polymerase chain reaction and histochemistry. We also measured serum-glucocorticoid-activated kinase 1 (Sgk1 mRNA), the number and phenotype of Iba1+ microglia, as well as mRNA expression levels of the pro-inflammatory factors cyclo-oxygenase 2 (Cox2), Nlrp3 inflammasome and tumour necrosis factor α (Tnfα). Expression of anti-inflammatory transforming growth factor (Tgf)β mRNA and the NADPH-diaphorase activity of nitric oxide synthase (NOS) were also determined. The results showed that, in the hippocampus of SHR rats, expression of MR and the number of immunoreactive MR/GR co-expressing cells were increased compared to Wistar-Kyoto control animals. Expression of Sgk1, Cox2, Nlrp3 and the number of ramified glia cells positive for Iba1+ were also increased, whereas Tgfβ mRNA expression and the NADPH-diaphorase activity of NOS were decreased. We propose that, in the SHR hippocampus, increased MR expression causes a bias towards a pro-inflammatory phenotype characteristic for hypertensive encephalopathy. Fil: Brocca, María Elvira. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Pietranera, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina Fil: Meyer, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Lima, Analia Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Roig, Paulina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: De Kloet, Edo Ronald. Leiden University; Países Bajos Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
- Subjects :
- 0301 basic medicine
Male
Endocrinology, Diabetes and Metabolism
Hippocampus
Hippocampal formation
Rats, Inbred WKY
neuroinflammation
0302 clinical medicine
Endocrinology
Mineralocorticoid receptor
Glucocorticoid receptor
Transforming Growth Factor beta
Rats, Inbred SHR
Neurons
purl.org/becyt/ford/3.1 [https]
Bioquímica y Biología Molecular
MINERALCORTICOID RECEPTOR
Medicina Básica
purl.org/becyt/ford/3 [https]
Microglia
medicine.medical_specialty
CIENCIAS MÉDICAS Y DE LA SALUD
hypertension
Neurociencias
Biology
Protein Serine-Threonine Kinases
NEUROINFLAMMATION
Immediate-Early Proteins
MICROGLIA
03 medical and health sciences
Cellular and Molecular Neuroscience
Spontaneously hypertensive rat
Receptors, Glucocorticoid
Internal medicine
medicine
Animals
Neuroinflammation
mineralocorticoid receptor
Inflammation
HYPERTENSION
Endocrine and Autonomic Systems
Rats
030104 developmental biology
Receptors, Mineralocorticoid
Cyclooxygenase 2
HIPPOCAMPUS
SGK1
Nitric Oxide Synthase
030217 neurology & neurosurgery
Transforming growth factor
Subjects
Details
- ISSN :
- 13652826
- Volume :
- 29
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of neuroendocrinology
- Accession number :
- edsair.doi.dedup.....c01bbe26407f78ddc4f213e4c52a5ce0