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One‐quarter of chronic hepatitis D patients reach HDV‐RNA decline or undetectability during the natural course of the disease
- Source :
- Alimentary Pharmacology & Therapeutics. 54:462-469
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- BACKGROUND Spontaneous HDV-RNA fluctuations, assessed by nonstandardised in-house assays, have been reported during the course of chronic hepatitis delta (CHD). AIMS To evaluate changes in serum HDV-RNA concentrations in untreated CHD patients and correlate these changes with other HBV markers. METHODS A total of 323 consecutive serum samples from 56 CHD patients (detectable HDV-RNA) followed for >3 years were retested for HDV-RNA levels by a sensitive technique using the first WHO international HDV-RNA standard. Quantitative HBsAg, HBV-DNA, and HBV-RNA were also determined. RESULTS Most participants were male, middle-aged, white European, and HBeAg-negative (82%). Almost half had liver cirrhosis and 64% were receiving nucleos(t)ide analogues. At inclusion, median-HDV-RNA was 5.3 (4.2-6.5) log10 IU/mL, HBsAg 4.0 (3.5-4.3) log10 IU/mL, and HBV-DNA 1.6 (1.0-2.6) log10 IU/mL; ALT values were normal in 13 (23%). During a mean follow-up of 5.6 (3-16) years, 14 (25%) showed ≥2log10 HDV-RNA decline, including 11 (20%) who spontaneously achieved undetectable HDV-RNA. Four patients (7%) lost HBsAg, with undetectable HDV-RNA. The remaining 42 (75%) had persistently detectable HDV-RNA. During follow-up, patients with a ≥2log10 HDV-RNA decline showed a greater HBsAg drop (-0.7 ± 1.1 vs -0.09 ± 0.9 log IU/mL; P = 0.039) than those with a
- Subjects :
- Male
Hepatitis B virus
HBsAg
medicine.medical_specialty
Cirrhosis
Hepatitis D, Chronic
viruses
Hbv markers
Disease
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Chronic hepatitis
Internal medicine
medicine
Humans
Pharmacology (medical)
030212 general & internal medicine
Natural course
Hepatitis B Surface Antigens
Hepatology
business.industry
virus diseases
Middle Aged
biochemical phenomena, metabolism, and nutrition
Serum samples
medicine.disease
Hepatitis D
DNA, Viral
RNA
Quantitative hbsag
030211 gastroenterology & hepatology
Hepatitis Delta Virus
business
Subjects
Details
- ISSN :
- 13652036 and 02692813
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Alimentary Pharmacology & Therapeutics
- Accession number :
- edsair.doi.dedup.....c012e02fc21bb41cc3444d9dae106873