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Functional pasta consumption in healthy volunteers modulates ABCG1-mediated cholesterol efflux capacity of HDL
- Publication Year :
- 2020
-
Abstract
- Prevention of cardiovascular (CV) disease is considered a central issue in public health and great attention is payed to nutritional approaches, including consumption of functional foods to reduce CV risk in individuals without indications for anti-atherosclerotic drugs. Cholesterol efflux capacity (CEC) is an important anti-atherogenic property of HDL and a marker of CV risk. We evaluated the effect of a daily consumption of an innovative whole-wheat synbiotic pasta, compared to a control whole-wheat pasta, on serum ATP binding cassette G1 (ABCG1)-mediated CEC in healthy overweight or obese individuals.Study participants (n = 41) were randomly allocated to either innovative or control pasta, consumed daily for twelve weeks. Serum CEC was measured before and after the dietary intervention, by a well-established radioisotopic technique on Chinese Hamster Ovary Cells transfected with human ABCG1. The innovative synbiotic pasta consumption was associated to a significantly higher post treatment/baseline ratio of ABCG1-mediated CEC values with respect to control pasta (mean ratio 1.05 ± 0.037 and 0.95 ± 0.042 respectively, p 0.05). Analysis of the relationship between ABCG1-mediated CEC and glycemia, homocysteine, total folates and interleukin-6 showed specific changes in the correlations between HDL function and glycemia, oxidative and inflammatory markers only after synbiotic pasta consumption.This is the first report on serum CEC improvement obtained by a new synbiotic functional pasta consumption, in absence of lipid profile modifications, in overweight/obese participants. This pilot study suggests that a simple dietary intervention can be a promising approach to CV preservation through improving of athero-protective HDL function.
- Subjects :
- Male
Synbiotic pasta
Time Factors
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Pilot Projects
Synbiotics
030204 cardiovascular system & hematology
Overweight
Subfamily G
chemistry.chemical_compound
0302 clinical medicine
Functional Food
Healthy volunteers
Medicine
Single-Blind Method
Cholesterol efflux
ATP Binding Cassette Transporter, Subfamily G, Member 1
Whole Grains
Nutrition and Dietetics
medicine.diagnostic_test
biology
food and beverages
Middle Aged
Cardiovascular disease
Metabolically Benign
Cholesterol
Treatment Outcome
ABCG1
Italy
Functional food
HDL function
Adult
Aged
Biomarkers
Cholesterol, HDL
Female
Humans
Obesity, Metabolically Benign
Diet, Healthy
Efflux
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Member 1
HDL
ATP Binding Cassette Transporter
030209 endocrinology & metabolism
03 medical and health sciences
Internal medicine
Obesity
Nutritional approaches
Healthy
business.industry
Diet
Endocrinology
chemistry
biology.protein
business
Lipid profile
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c00c7325edd91a6244416b51455e7490