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Current Technologies and Recent Developments for Screening of HPV-Associated Cervical and Oropharyngeal Cancers
- Source :
- Cancers, Vol 8, Iss 9, p 85 (2016), Cancers
- Publication Year :
- 2016
- Publisher :
- MDPI AG, 2016.
-
Abstract
- Mucosal infection by the human papillomavirus (HPV) is responsible for a growing number of malignancies, predominantly represented by cervical cancer and oropharyngeal squamous cell carcinoma. Because of the prevalence of the virus, persistence of infection, and long latency period, novel and low-cost methods are needed for effective population level screening and monitoring. We review established methods for screening of cervical and oral cancer as well as commercially-available techniques for detection of HPV DNA. We then describe the ongoing development of microfluidic nucleic acid-based biosensors to evaluate circulating host microRNAs that are produced in response to an oncogenic HPV infection. The goal is to develop an ideal screening platform that is low-cost, portable, and easy to use, with appropriate signal stability, sensitivity and specificity. Advances in technologies for sample lysis, pre-treatment and concentration, and multiplexed nucleic acid detection are provided. Continued development of these devices provides opportunities for cancer screening in low resource settings, for point-of-care diagnostics and self-screening, and for monitoring response to vaccination or surgical treatment.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Review
Biology
lcsh:RC254-282
Virus
03 medical and health sciences
Internal medicine
Cancer screening
medicine
diagnostics
human papillomavirus
HPV DNA
Cervical cancer
microRNA
HPV infection
Cancer
integrated platform
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
3. Good health
Mucosal Infection
E6/E7 genotypes
Vaccination
Hpv testing
030104 developmental biology
Immunology
cervical and oropharyngeal cancers
Subjects
Details
- Language :
- English
- ISSN :
- 20726694
- Volume :
- 8
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....c00254d0ffc59222fd83e1c96cd1fca2