Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation

Authors :: Susan L. Morris-Natschke
Wang Yunsong
Jing-Hua Yang
Lu Rong
Yung Yi Cheng
Meng-Han Zhang
Wang Xinyi
Kuo Hsiung Lee
Yi-Ping Zhou
Chin Ho Chen
Source :: Molecules, Vol 25, Iss 1, p 99 (2019), Molecules, Volume 25, Issue 1
Publication Year :: 2019
Publisher :: MDPI AG, 2019.
Abstract: Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3&ndash<br />8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1&ndash<br />8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 &mu<br />g/mL and SI of 7.1.

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