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Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern
- Source :
- European Psychiatry. 27:369-371
- Publication Year :
- 2012
- Publisher :
- Cambridge University Press (CUP), 2012.
-
Abstract
- This case-control study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 (an orphan member of the G protein-coupled melatonin receptor subfamily) in females. This may represent a gender-specific risk factor and a molecular link between melatonin and SAD.
- Subjects :
- Male
Subfamily
Genotype
Nerve Tissue Proteins
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Melatonin receptor
Genetic determinism
Receptors, G-Protein-Coupled
Melatonin
03 medical and health sciences
Sex Factors
0302 clinical medicine
Genes, X-Linked
medicine
Humans
Genetic Predisposition to Disease
Gene
Genetic Association Studies
Genetics
030505 public health
Seasonal Affective Disorder
030229 sport sciences
medicine.disease
Introns
Psychiatry and Mental health
Mood disorders
GPR50
Case-Control Studies
Female
0305 other medical science
medicine.drug
Subjects
Details
- ISSN :
- 17783585 and 09249338
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- European Psychiatry
- Accession number :
- edsair.doi.dedup.....bfea31c44725fb285460fdc52d9f1fd8
- Full Text :
- https://doi.org/10.1016/j.eurpsy.2011.02.011