Back to Search
Start Over
Extracellular Vesicles miRNA Cargo for Microglia Polarization in Traumatic Brain Injury
- Source :
- Biomolecules, Biomolecules, Vol 10, Iss 901, p 901 (2020)
- Publication Year :
- 2020
-
Abstract
- Traumatic brain injury (TBI) is one of the major causes of death and disability worldwide, and despite its high dissemination, effective pharmacotherapies are lacking. TBI can be divided into two phases: the instantaneous primary mechanical injury, which occurs at the moment of insult, and the delayed secondary injury, which involves a cascade of biological processes that lead to neuroinflammation. Neuroinflammation is a hallmark of both acute and chronic TBI, and it is considered to be one of the major determinants of the outcome and progression of disease. In TBI one of the emerging mechanisms for cell–cell communication involved in the immune response regulation is represented by Extracellular Vesicles (EVs). These latter are produced by all cell types and are considered a fingerprint of their generating cells. Exosomes are the most studied nanosized vesicles and can carry a variety of molecular constituents of their cell of origin, including microRNAs (miRNAs). Several miRNAs have been shown to target key neuropathophysiological pathways involved in TBI. The focus of this review is to analyze exosomes and their miRNA cargo to modulate TBI neuroinflammation providing new strategies for prevent long-term progression of disease.
- Subjects :
- 0301 basic medicine
Cell type
Traumatic brain injury
lcsh:QR1-502
microglia
Disease
Review
Exosomes
Biochemistry
lcsh:Microbiology
neuroinflammation
03 medical and health sciences
Extracellular Vesicles
0302 clinical medicine
Immune system
microRNA
Brain Injuries, Traumatic
TBI
medicine
Animals
Humans
Molecular Biology
Neuroinflammation
Microglia
business.industry
Cell Polarity
Biological Transport
medicine.disease
Microvesicles
MicroRNAs
030104 developmental biology
medicine.anatomical_structure
miRNAs
Disease Progression
Encephalitis
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 2218273X
- Volume :
- 10
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Biomolecules
- Accession number :
- edsair.doi.dedup.....bfe07d169e67172786a14e0029dce17d