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Association of Genetic Variants of NLRP4 with Exacerbation of Asthma: The Effect of Smoking
- Source :
- DNA and Cell Biology. 38:76-84
- Publication Year :
- 2019
- Publisher :
- Mary Ann Liebert Inc, 2019.
-
Abstract
- Asthma exacerbation is induced by the interaction of genes and environmental factors such as cigarette smoke. NLRP4 counteracts the activity of the inflammasome, which is responsible for asthma exacerbation. In this study, we analyzed the association of single-nucleotide polymorphisms of NLRP4 with the annual rate of exacerbation and evaluated the additive effect of smoking in 1454 asthmatics. Asthmatics possessing the minor allele of rs1696718G A had more frequent exacerbation episodes than those homozygous for the common allele (0.59 vs. 0.36/year) and the association was present only in current and ex-smokers. There was a significant interaction between the amount smoked and rs16986718 genotypes (p = 0.014) and a positive correlation between the number of annual exacerbation episodes and amount smoked only in rs16986718G A AA homozygotes. The prevalence of frequent exacerbators (≥2 exacerbation episodes/year) was 2.5 times higher in rs16986718G A minor allele homozygotes than in common allele homozygotes (12.0% vs. 5.9%). Furthermore, the prevalence was 6 times higher in rs16986718G A minor allele homozygotes who were current and ex-smokers than in nonsmokers (25.6% vs. 4.1%). The minor allele of rs16986718G A in NLRP4 may be a genetic marker that predicts asthma exacerbation in adult asthmatics who smoke.
- Subjects :
- Adult
Male
0301 basic medicine
Genotype
Exacerbation
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Young Adult
03 medical and health sciences
0302 clinical medicine
immune system diseases
Prevalence
Genetics
medicine
Humans
Gene–environment interaction
Molecular Biology
Gene
Alleles
Adaptor Proteins, Signal Transducing
Asthma
Asthma exacerbations
Smoking
Genetic variants
Genetic Variation
Inflammasome
Cell Biology
General Medicine
Middle Aged
medicine.disease
respiratory tract diseases
Repressor Proteins
030104 developmental biology
030220 oncology & carcinogenesis
Immunology
Female
Gene-Environment Interaction
medicine.drug
Subjects
Details
- ISSN :
- 15577430 and 10445498
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- DNA and Cell Biology
- Accession number :
- edsair.doi.dedup.....bfdf12ad5177df5f68745c150fbdb5fa