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Molecular mechanism study of HGF/c-MET pathway activation and immune regulation for a tumor diagnosis model
- Source :
- Cancer Cell International, Vol 21, Iss 1, Pp 1-15 (2021), Cancer Cell International
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background Hepatocyte growth factor (HGF) binds to the c-mesenchymal-epithelial transition (C-MET) receptor and activates downstream signaling pathways, playing an essential role in the development of various cancers. Given the role of this signaling pathway, the primary therapeutic direction focuses on identifying and designing HGF inhibitors, antagonists and other molecules to block the binding of HGF to C-MET, thereby limiting the abnormal state of other downstream genes. Methods This study focuses on the analysis of immune-related genes and corresponding immune functions that are significantly associated with the HGF/c-MET pathway using transcriptome data from 11 solid tumors. Results We systematically analyzed 11 different cancers, including expression correlation, immune infiltration, tumor diagnosis and survival prognosis from HGF/c-MET pathway and immune regulation, two biological mechanisms having received extensive attention in cancer analysis. Conclusion We found that the HGF/c-MET pathway affected the tumor microenvironment mainly by interfering with expression levels of other genes. Immune infiltration is another critical factor involved in changes to the tumor microenvironment. The downstream immune-related genes activated by the HGF/c-MET pathway regulate immune-related pathways, which in turn affect the degree of infiltration of immune cells. Immune infiltration is significantly associated with cancer development and prognosis.
- Subjects :
- 0301 basic medicine
Cancer Research
C-Met
Biology
Transcriptome
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Immune system
Genetics
medicine
HGF
Pathway score
Receptor
RC254-282
c-MET
Tumor microenvironment
Diagnostic predictor
QH573-671
Immune cells
Cancer
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
medicine.disease
RNAseq
Immune infiltration
030104 developmental biology
Oncology
chemistry
030220 oncology & carcinogenesis
Cancer research
Hepatocyte growth factor
Signal transduction
Primary Research
Cytology
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14752867
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cancer Cell International
- Accession number :
- edsair.doi.dedup.....bfdbf02f9146adbb8128fdaf6ef1b605