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Low cerebrospinal fluid protein in prepubertal children with idiopathic intracranial hypertension
- Source :
- Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus. 19(2)
- Publication Year :
- 2014
-
Abstract
- Purpose To evaluate a clinical observation that prepubertal children with idiopathic intracranial hypertension (IIH) have low cerebrospinal fluid (CSF) protein levels compared to healthy children and pubertal patients with IIH. Methods The medical records of prepubertal and pubertal IIH patients and controls seen in the pediatric neuro-ophthalmology clinic at Duke between 2003 and 2013 were retrospectively reviewed. The control group consisted of children who had normal intracranial pressure on lumbar puncture performed to evaluate for headaches or anomalous-looking optic nerves. The records were analyzed with attention to demographic characteristics, clinical presentation, course, and lumbar puncture results. Results A total of 23 prepubertal children with IIH (age range, 0.75-13 years), 16 pubertal patients with IIH (age range, 13-21 years), and 12 controls (age range 3-14 years) were included. CSF analysis revealed that prepubertal children with IIH had significantly lower CSF protein levels (17.3 ± 5.7 mg/dL) compared to pubertal subjects with IIH (23.4 ± 8.4 mg/dL; P = 0.019) or healthy controls (23.5 ± 6.4 mg/dL; P = 0.011). Furthermore, 9 of 23 prepubertal IIH patients (39%) had abnormally low CSF protein level ( P = 0.005) and zero controls ( P = 0.015). Acetazolamide increased CSF protein level in 100% of patients who underwent repeat lumbar puncture after starting the medication (average increase, 10.3 ± 6.6 mg/dL). Conclusions Low CSF protein level may have diagnostic utility as a biomarker for prepubertal IIH. Furthermore, this finding suggests that some cases of prepubertal IIH may be caused by CSF overproduction rather than decreased CSF resorption.
- Subjects :
- Male
medicine.medical_specialty
Adolescent
Intracranial Pressure
Pseudotumor cerebri
Gastroenterology
Spinal Puncture
Young Adult
Cerebrospinal fluid
Internal medicine
medicine
Humans
Papilledema
Child
CSF albumin
Intracranial pressure
Retrospective Studies
Pseudotumor Cerebri
medicine.diagnostic_test
Lumbar puncture
business.industry
Puberty
Infant
Cerebrospinal Fluid Proteins
medicine.disease
Ophthalmology
Endocrinology
Child, Preschool
Pediatrics, Perinatology and Child Health
Female
Headaches
medicine.symptom
business
Acetazolamide
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 15283933
- Volume :
- 19
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
- Accession number :
- edsair.doi.dedup.....bfdaa72449ed40ba73fe1759d991602e