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Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: importance in the control of blood pressure and hypertension
- Source :
- FEBS letters, FEBS LETTERS
- Publication Year :
- 2013
-
Abstract
- In this review, we discuss genetic evidence supporting Guyton’s hypothesis stating that blood pressure control is critically depending on fluid handling by the kidney. The review is focused on the genetic dissection of sodium and potassium transport in the distal nephron and the collecting duct that are the most important sites for the control of sodium and potassium balance by aldosterone and angiotensin II. Thanks to the study of Mendelian forms of hypertension and their corresponding transgenic mouse models, three main classes of diuretic receptors (furosemide, thiazide, amiloride) and the main components of the aldosterone- and angiotensin-dependent signaling pathways were molecularly identified over the past 20years. This will allow to design rational strategies for the treatment of hypertension and for the development of the next generation of diuretics.
- Subjects :
- medicine.medical_specialty
Potassium Channels
Sodium-Potassium-Chloride Symporters
Biophysics
Blood Pressure
030204 cardiovascular system & hematology
Pharmacology
Transgenic mouse model
Biochemistry
Sodium Channels
Angiotensin
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Structural Biology
Internal medicine
Renin–angiotensin system
Genetics
medicine
Animals
Humans
Diuretics
Aldosterone
Molecular Biology
Thiazide
030304 developmental biology
0303 health sciences
Sodium
Furosemide
Biological Transport
Nephrons
Cell Biology
medicine.disease
Angiotensin II
3. Good health
Amiloride
Blood pressure
Endocrinology
chemistry
Pathophysiology of hypertension
Mutation
Hypertension
Potassium
Kidney Diseases
Signal Transduction
medicine.drug
Subjects
Details
- Volume :
- 587
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- FEBS letters
- Accession number :
- edsair.doi.dedup.....bfd0048dc8c0921e00b308c7498439cf