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CAJAL BODIES: A Long History of Discovery
- Source :
- Annual Review of Cell and Developmental Biology. 21:105-131
- Publication Year :
- 2005
- Publisher :
- Annual Reviews, 2005.
-
Abstract
- This review surveys what is known about the structure and function of the subnuclear domains called Cajal bodies (CBs). The major focus is on CBs in mammalian cells but we provide an overview of homologous CB structures in other organisms. We discuss the protein and RNA components of CBs, including factors recently found to associate in a cell cycle-dependent fashion or under specific metabolic or stress conditions. We also consider the dynamic properties of both CBs and their molecular components, based largely on recent data obtained thanks to the advent of improved in vivo detection and imaging methods. We discuss how these data contribute to an understanding of CB functions and highlight major questions that remain to be answered. Finally, we consider the interesting links that have emerged between CBs and alterations in nuclear structure apparent in a range of human pathologies, including cancer and inherited neurodegenerative diseases. We speculate on the relationship between CB function and molecular disease.
- Subjects :
- Cell Nucleus
Intranuclear Inclusion Bodies
RNA-Binding Proteins
Molecular Disease
Coiled Bodies
Cell Biology
History, 20th Century
Biology
Ribonucleoproteins, Small Nuclear
Bioinformatics
Models, Biological
Structure and function
Cajal body
Animals
Humans
Coilin
Stress conditions
Histone locus body
Neuroscience
Function (biology)
Forecasting
Developmental Biology
Subjects
Details
- ISSN :
- 15308995 and 10810706
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Annual Review of Cell and Developmental Biology
- Accession number :
- edsair.doi.dedup.....bfce45f376146fbdfa564b488e7c9fce