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Prognostic value of ASXL1 mutations in patients with primary myelofibrosis and its relationship with clinical features: a meta-analysis
- Source :
- Annals of Hematology
- Publication Year :
- 2020
-
Abstract
- Additional sex combs like 1 (ASXL1) mutations are one of the most common molecular biological abnormalities in patients with primary myelofibrosis (PMF), and the effect of these mutations on prognosis remains controversial. Hence, we conducted a meta-analysis to assess the prognostic value and clinical characteristics of ASXL1 mutations in PMF patients. Eligible studies were systematically searched from PubMed, Embase, and the Cochrane Library. We extracted the hazard ratios (HRs) and their 95% confidence intervals (CIs) of overall survival (OS) and leukemia-free survival (LFS), the number of patients transformed to acute leukemia, and clinical characteristics to carry out a meta-analysis by fixed effect model or random effect model according to the heterogeneity between studies. A total of 4501 PMF patients from 16 cohorts of 14 studies were included in this meta-analysis. The results revealed that ASXL1 mutations might predict a shorter OS (HR = 2.30, 95% CI: 1.79–2.94, P P = 0.0003; the rate of acute leukemia transformation: OR = 2.06, 95% CI: 1.50–2.83, P
- Subjects :
- Oncology
Male
medicine.medical_specialty
Carcinogenesis
Cochrane Library
Disease-Free Survival
Sex Factors
Internal medicine
medicine
Humans
Myelofibrosis
Aged
Acute leukemia
Hematology
Leukemia
business.industry
Hazard ratio
Age Factors
Clinical features
General Medicine
Random effects model
medicine.disease
Confidence interval
Neoplasm Proteins
ASXL1 mutations
Repressor Proteins
Survival Rate
Meta-analysis
Primary myelofibrosis
Acute Disease
Mutation
Female
Original Article
business
Prognostic value
Subjects
Details
- ISSN :
- 14320584
- Volume :
- 100
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Annals of hematology
- Accession number :
- edsair.doi.dedup.....bfc72ff1184d7a218e778546616ffe0d