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Response to HAART and GB virus type C coinfection in a cohort of antiretroviral-naive HIV-infected individuals
- Source :
- Scopus-Elsevier
-
Abstract
- The prognostic role of GB virus type C (GBV-C) viraemia in HIV-infected subjects treated with highly active antiretroviral therapy (HAART) is still undefined, The aim of this analysis is to assess the relationship between GBV-C infection and response to antiretroviral therapy among HIV-infected subjects initiating HAART when antiretroviral-naive. A prospective, observational study of 400 HIV-infected patients with measurements of GBV-C RNA, hepatitis C virus (HCV) antibodies and HCV RNA determined from plasma stored prior to HAART initiation, Time to virological (achieving HIV RNA ≤500 copies/ml) and immunological success (a CD4+ count increase of ≥200cells/μl), and the time to virological relapse (confirmed HIV RNA >500 copies/ml) were assessed by Kaplan-Meier methods and Cox proportional hazard regression model. Of the subjects, 117 (29.3%) were GBV-C positive and, overall, 351 (87.8%) patients achieved virological success, After controlling for a number of confounders including HCV RNA, GBV-C viraemic patients experienced a significantly lower risk of HIV rebound than those who were GBV-C negative [relative hazard (RH)=0.56, 95% CI: 0.34–0.93, P=0.03], Conversely, the probability of achieving initial virological success or CD4+ count response after HAART did not differ between GBV-C-negative and -positive subjects, These results suggest that GBV-C coinfection may play a role in determining the rate of HIV rebound possibly by competing with HIV replication after HIV load has been successfully suppressed by HAART.
- Subjects :
- Adult
Male
Viremia
GB virus C
HIV Infections
Virus
Cohort Studies
Acquired immunodeficiency syndrome (AIDS)
Antiretroviral Therapy, Highly Active
Medicine
Humans
Pharmacology (medical)
Prospective Studies
Sida
Pharmacology
biology
Base Sequence
business.industry
virus diseases
Flaviviridae Infections
Hepatitis C Antibodies
biology.organism_classification
medicine.disease
Virology
Flavivirus
Infectious Diseases
Cohort
Immunology
DNA, Viral
Coinfection
RNA, Viral
Female
Viral disease
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....bfc7013510fe0110b34ac29fdb9c6f31