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The mechano-gated K2P channel TREK-1
- Source :
- Biophysics of structure and mechanism, Biophysics of structure and mechanism, Springer-Verlag, 2009, 38 (3), pp.293-303. ⟨10.1007/s00249-008-0318-8⟩
- Publication Year :
- 2008
- Publisher :
- Springer Science and Business Media LLC, 2008.
-
Abstract
- The versatility of neuronal electrical activity is largely conditioned by the expression of different structural and functional classes of K+ channels. More than 80 genes encoding the main K+ channel alpha subunits have been identified in the human genome. Alternative splicing, heteromultimeric assembly, post-translational modification and interaction with auxiliary regulatory subunits further increase the molecular and functional diversity of K+ channels. Mammalian two-pore domain K+ channels (K(2P)) make up one class of K+ channels along with the inward rectifiers and the voltage- and/or calcium-dependent K+ channels. Each K(2P) channel subunit is made up of four transmembrane segments and two pore-forming (P) domains, which are arranged in tandem and function as either homo- or heterodimeric channels. This novel structural arrangement is associated with unusual gating properties including "background" or "leak" K+ channel activity, in which the channels show constitutive activity at rest. In this review article, we will focus on the lipid-sensitive mechano-gated K(2P) channel TREK-1 and will emphasize on the polymodal function of this "unconventional" K+ channel.
- Subjects :
- MESH: Hydrogen-Ion Concentration
Biophysics
KcsA potassium channel
Nanotechnology
MESH: Receptors, G-Protein-Coupled
Biology
Second Messenger Systems
Receptors, G-Protein-Coupled
SK channel
Membrane Lipids
03 medical and health sciences
Potassium Channels, Tandem Pore Domain
0302 clinical medicine
Animals
Humans
MESH: Animals
Phospholipids
Ion channel
030304 developmental biology
MESH: Phospholipids
0303 health sciences
MESH: Stress, Mechanical
MESH: Humans
Voltage-gated ion channel
Inward-rectifier potassium ion channel
Temperature
MESH: Potassium Channels, Tandem Pore Domain
MESH: Fatty Acids, Unsaturated
General Medicine
Hydrogen-Ion Concentration
MESH: Ion Channel Gating
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
Light-gated ion channel
MESH: Temperature
MESH: Second Messenger Systems
Fatty Acids, Unsaturated
Ligand-gated ion channel
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Mechanosensitive channels
Stress, Mechanical
MESH: Membrane Lipids
Ion Channel Gating
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14321017, 01757571, and 03401057
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- European Biophysics Journal
- Accession number :
- edsair.doi.dedup.....bfbebb61b1db12edb24c6e892430ff94