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CD28 deletion improves obesity-induced liver steatosis but increases adiposity in mice
- Source :
- International Journal of Obesity, International Journal of Obesity, Nature Publishing Group, 2015, 39 (6), pp.977-85, International Journal of Obesity, Nature Publishing Group, 2015, 39 (6), pp.977-85. ⟨10.1038/ijo.2015.26⟩, International Journal of Obesity, 2015, 39 (6), pp.977-85. ⟨10.1038/ijo.2015.26⟩, International Journal of Obesity, Nature Publishing Group, 2015
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- International audience; Lymphocytes have a critical role in visceral adipose tissue (AT) inflammation. The CD28 costimulatory molecule is required for lymphocyte activation and for the development of a functional regulatory T cells (Tregs) compartment; however, its role during obesity is unknown.During diet-induced obesity, we investigated the effects of selective interference with CD28 signaling using knockout mice (Cd28KO) and a CTLA4-Ig fusion protein inhibiting CD28-B7 interactions.Cd28 deficiency decreased pathogenic T cells and Treg content within AT without changing the macrophages number. Cd28KO epididymal but not subcutaneous fat was characterized by enlarged adipocytes, reduced levels of inflammatory cytokines and increased Glut4, adiponectin and lipogenic enzyme mRNA levels. This was associated with reduced inflammation, fat accumulation and enhanced glucose metabolism in liver. Weight gain and fasting glucose tolerance were not affected. CTLA4-Ig injections reduced the number of T cells in epididymal AT (epiAT) but not the inflammatory cytokines levels and failed to improve liver fat accumulation.Deletion of CD28 creates a new pro/anti-inflammatory balance in epiAT and liver and exerts a protective effect against hepatic steatosis.
- Subjects :
- Male
MESH: Inflammation
MESH: Antigens, CD28
Endocrinology, Diabetes and Metabolism
MESH: Antigens, CD27
Medicine (miscellaneous)
Adipose tissue
[SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
MESH: Mice, Knockout
Mice
MESH: Obesity
MESH: Animals
MESH: Fatty Liver
ComputingMilieux_MISCELLANEOUS
MESH: Lipid Metabolism
Mice, Knockout
Nutrition and Dietetics
biology
Chemistry
Intracellular Signaling Peptides and Proteins
CD28
3. Good health
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
MESH: Insulin Resistance
Adipose Tissue
Liver
medicine.symptom
MESH: Adipose Tissue
medicine.medical_specialty
[SDV.IMM] Life Sciences [q-bio]/Immunology
Inflammation
chemical and pharmacologic phenomena
Proinflammatory cytokine
Insulin resistance
CD28 Antigens
MESH: Mice, Inbred C57BL
Internal medicine
MESH: Intracellular Signaling Peptides and Proteins
medicine
Animals
Obesity
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
MESH: Mice
Adiponectin
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology
Lipid Metabolism
medicine.disease
MESH: Male
Tumor Necrosis Factor Receptor Superfamily, Member 7
Fatty Liver
Mice, Inbred C57BL
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
Disease Models, Animal
Endocrinology
MESH: Gene Deletion
biology.protein
Insulin Resistance
Steatosis
MESH: Disease Models, Animal
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Gene Deletion
GLUT4
MESH: Liver
Subjects
Details
- Language :
- English
- ISSN :
- 03070565 and 14765497
- Database :
- OpenAIRE
- Journal :
- International Journal of Obesity, International Journal of Obesity, Nature Publishing Group, 2015, 39 (6), pp.977-85, International Journal of Obesity, Nature Publishing Group, 2015, 39 (6), pp.977-85. ⟨10.1038/ijo.2015.26⟩, International Journal of Obesity, 2015, 39 (6), pp.977-85. ⟨10.1038/ijo.2015.26⟩, International Journal of Obesity, Nature Publishing Group, 2015
- Accession number :
- edsair.doi.dedup.....bfbbfb21739d54bb7a04e7115f8c9132