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The effects of atrial natriuretic peptide on electroconvulsive shock-induced amnesia in rats. Transmitter-mediated action
- Source :
- Neuropeptides. 19:103-106
- Publication Year :
- 1991
- Publisher :
- Elsevier BV, 1991.
-
Abstract
- Electroconvulsive shock (ECS) applied immediately after passive avoidance learning in rats caused partial amnesia. This could be prevented by administering r-ANP into the lateral brain ventricle. The effects of pre-treatment with different receptor blockers: (haloperidol, atropine, phenoxybenzamine, propranolol, naloxone, bicuculline and methysergide) on the ANP-induced antiamnesia were investigated. The receptor blockers per se in the doses selected had no influence on the ECS-induced amnesia. Haloperidol, atropine and propranolol blocked the antiamnestic action of the peptide, while phenoxybenzamine, naloxone, bicuculline and methysergide were ineffective. The results confirm our previous observations that ANP might play a role in learning and memory processes and also suggest that the antiamnestic action of the peptide is mediated by dopaminergic, cholinergic and beta-adrenergic mediator systems.
- Subjects :
- Atropine
Male
medicine.medical_specialty
Phenoxybenzamine
Methysergide
Amnesia
(+)-Naloxone
Propranolol
Bicuculline
Cellular and Molecular Neuroscience
Endocrinology
Atrial natriuretic peptide
Memory
Internal medicine
Avoidance Learning
Haloperidol
Animals
Medicine
Electroshock
Naloxone
Endocrine and Autonomic Systems
business.industry
General Medicine
Rats
Neurology
medicine.symptom
business
Atrial Natriuretic Factor
medicine.drug
Subjects
Details
- ISSN :
- 01434179
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Neuropeptides
- Accession number :
- edsair.doi.dedup.....bfb5d90fd97be84dd61b505d6c0beb8f