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Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?
- Source :
- International Journal of Cardiology. 236:237-243
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Ivabradine is an inhibitor of mixed NaIn 12 isolated rabbit hearts AF was induced in 7 of 12 hearts (13 episodes) under baseline conditions by a standardized protocol employing atrial burst pacing. Thereafter, a combination of acetylcholine and isoproterenol was employed to enhance AF occurrence. Monophasic action potential recordings showed a decrease of atrial action potential duration (aAPD,-37ms, p0.05) and atrial effective refractory period (aERP;-39ms, p0.05) after infusion of both acetycholine (1μM) and isoproterenol (1μM) as compared with baseline. This led to induction of AF in 11 of 12 hearts (124 episodes). Simultaneous infusion of ivabradine (3μM) led to a significant reduction of AF (6 of 11 hearts, 63 episodes). Ivabradine induced an increase of aAPD (+9ms) and aERP (+30ms, p0.05) leading to a marked increase of atrial post-repolarization refractoriness (aPRR), defined as the difference of aERP and aAPD (+21ms, p0.05). Results were compared to 10 rabbits treated with flecainide. Flecainide treatment also induced a significant increase of aPRR and resulted in induction of AF in 6 of 10 hearts (58 episodes) while 9 of 10 hearts were inducible during sole treatment with acetylcholine and isoproterenol (129 episodes).In the present experimental study, administration of ivabradine reduced inducibility of AF and therefore may represent a supplemental therapeutic option in AF. Of note, its antiarrhythmic efficacy was comparable to the established agent flecainide.
- Subjects :
- 0301 basic medicine
Drug
medicine.medical_specialty
Atrial action potential
media_common.quotation_subject
Action Potentials
030204 cardiovascular system & hematology
03 medical and health sciences
Drug Delivery Systems
Organ Culture Techniques
0302 clinical medicine
Internal medicine
Atrial Fibrillation
medicine
Animals
Ivabradine
Flecainide
media_common
business.industry
Cardiovascular Agents
Atrial fibrillation
Benzazepines
medicine.disease
Treatment Outcome
030104 developmental biology
Heart failure
Cardiovascular agent
Cardiology
Rabbits
Cardiology and Cardiovascular Medicine
business
Acetylcholine
medicine.drug
Subjects
Details
- ISSN :
- 01675273
- Volume :
- 236
- Database :
- OpenAIRE
- Journal :
- International Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....bfb16485eb4ff2987fc76d0d7265361f