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Variations in Brain Volume and Growth in Young Children With Type 1 Diabetes
- Source :
- Diabetes. 65(2)
- Publication Year :
- 2015
-
Abstract
- Early-onset type 1 diabetes may affect the developing brain during a critical window of rapid brain maturation. Structural MRI was performed on 141 children with diabetes (4–10 years of age at study entry) and 69 age-matched control subjects at two time points spaced 18 months apart. For the children with diabetes, the mean (±SD) HbA1c level was 7.9 ± 0.9% (63 ± 9.8 mmol/mol) at both time points. Relative to control subjects, children with diabetes had significantly less growth of cortical gray matter volume and cortical surface area and significantly less growth of white matter volume throughout the cortex and cerebellum. For the population with diabetes, the change in the blood glucose level at the time of scan across longitudinal time points was negatively correlated with the change in gray and white matter volumes, suggesting that fluctuating glucose levels in children with diabetes may be associated with corresponding fluctuations in brain volume. In addition, measures of hyperglycemia and glycemic variation were significantly negatively correlated with the development of surface curvature. These results demonstrate that early-onset type 1 diabetes has widespread effects on the growth of gray and white matter in children whose blood glucose levels are well within the current treatment guidelines for the management of diabetes.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Population
030209 endocrinology & metabolism
White matter
03 medical and health sciences
0302 clinical medicine
Internal medicine
Diabetes mellitus
Internal Medicine
Medicine
Humans
Longitudinal Studies
Gray Matter
education
Child
Glycemic
Type 1 diabetes
education.field_of_study
medicine.diagnostic_test
business.industry
Case-control study
Age Factors
Brain
Magnetic resonance imaging
Organ Size
medicine.disease
Magnetic Resonance Imaging
White Matter
medicine.anatomical_structure
Endocrinology
Diabetes Mellitus, Type 1
Case-Control Studies
Child, Preschool
Hyperglycemia
Brain size
Female
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1939327X
- Volume :
- 65
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi.dedup.....bfb02884f70ecfd77d36ad9f79addabb