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Mono-guanidine heterolipid based SMEDDS: A promising tool for cytosolic delivery of antineoplastics
- Source :
- Biomaterials. 57
- Publication Year :
- 2014
-
Abstract
- In the present work, we designed and synthesized a novel mono-guanidine heterolipid (MGH) and confirmed its structure by NMR and ESI-MS. The MGH was used as cationic lipid in developing etoposide loaded cationic self-microemulsifying drug delivery system (ECS) intended to be delivered by intratumoral route. The ECS exhibited size
- Subjects :
- Drug
Materials science
Side effect
media_common.quotation_subject
Biophysics
Biological Availability
Bioengineering
Antineoplastic Agents
Pharmacology
Nephrotoxicity
Biomaterials
Drug Delivery Systems
Cell Line, Tumor
medicine
Animals
Melanoma
Etoposide
Guanidine
media_common
Cell Proliferation
Drug Carriers
Transfection
medicine.disease
Lipids
Mice, Inbred C57BL
Cytosol
Solubility
Mechanics of Materials
Drug delivery
Ceramics and Composites
Emulsions
Female
medicine.drug
Subjects
Details
- ISSN :
- 18785905
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Biomaterials
- Accession number :
- edsair.doi.dedup.....bfa2fbdd6ec940405a7d33fab8ca3775