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Acute toxicity related to misuse (nonmedical use) of tramadol: Experience of the European Drug Emergencies Network Plus
- Source :
- British Journal of Clinical Pharmacology, British Journal of Clinical Pharmacology, 2021, 87 (4), pp.1668-1675. ⟨10.1111/bcp.14408⟩
- Publication Year :
- 2020
-
Abstract
- International audience; Following the development of the tramadol crisis currently affecting countries in the Middle East, and Africa, there has been increasing international interest in the regulation of tramadol. This study investigates the misuse of tramadol in patients presenting to emergency departments across Europe. Data from 32 emergency departments in 21 countries were extracted from the Euro-DEN Plus database for the 4-year period from 1 January 2014 to 31 December 2017. Of the reported 24,957 emergency department presentations, tramadol misuse was reported in 105 (0.4% presentations). Tramadol misuse was most common in Bratislava (Slovakia; n = 11, 7.5% of all presentations to this centre), Riga (Latvia; n = 4, 4.9%) and Munich (Germany; n = 17, 2.9%). On arrival, 14 (13.3%) of presentations were in coma/Glasgow coma score ≤ 8 and 9 of these had a respiratory rate
- Subjects :
- medicine.medical_specialty
030226 pharmacology & pharmacy
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
03 medical and health sciences
0302 clinical medicine
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Germany
Medicine
Humans
Pharmacology (medical)
In patient
030212 general & internal medicine
Tramadol
Pharmacology
Coma
[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases
business.industry
Glasgow Coma Scale
Emergency department
humanities
[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
[SDV.TOX] Life Sciences [q-bio]/Toxicology
Analgesics, Opioid
Europe
Pharmaceutical Preparations
[SDV.TOX]Life Sciences [q-bio]/Toxicology
Emergency medicine
Africa
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
medicine.symptom
Emergencies
business
Emergency Service, Hospital
medicine.drug
Subjects
Details
- ISSN :
- 13652125 and 03065251
- Volume :
- 87
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- British journal of clinical pharmacologyREFERENCES
- Accession number :
- edsair.doi.dedup.....bf9697e8e7284a0352de751895d3e90f