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Exhaled Nitric Oxide Changes During Acclimatization to High Altitude: A Descriptive Study
- Source :
- High Altitude Medicine & Biology. 19:215-220
- Publication Year :
- 2018
- Publisher :
- Mary Ann Liebert Inc, 2018.
-
Abstract
- Summerfield, Douglas T., Kirsten E. Coffman, Bryan J. Taylor, Amine N. Issa, and Bruce D. Johnson. Exhaled nitric oxide changes during acclimatization to high altitude: a descriptive study. High Alt Med Biol. 19:215-220, 2018.This study describes differences in the partial pressures of exhaled nitric oxide (PeNO) between subjects fully acclimatized (ACC) to 5300 m and those who have just arrived to high altitude.PeNO was determined in eight subjects newly exposed and nonacclimatized (non-ACC) to high altitude and compared with that in nine subjects who had ACC to high altitude for 1 month. In addition, systolic pulmonary artery pressure (sPAP) and arterial oxygen saturation (SaOPeNO levels on day 1 were significantly higher in the non-ACC versus ACC cohort (8.7 ± 3.5 vs. 3.9 ± 2.2 nmHg, p = 0.004). As the non-ACC group remained at altitude, PeNO levels fell and were not different when compared with those of the ACC group by day 9 (5.9 ± 2.4 vs. 3.9 ± 2.2 nmHg, p = 0.095). Higher sPAP was correlated with lower PeNO levels in all participants (R = -0.50, p = 0.043). PeNO levels were not correlated with SaOAs individuals acclimatized to high altitude, PeNO levels decreased. Even after acclimatization, PeNO levels continued to play a role in pulmonary vascular tone.
- Subjects :
- Male
Time Factors
Physiology
Acclimatization
Partial Pressure
Pulmonary Artery
030204 cardiovascular system & hematology
Nitric Oxide
03 medical and health sciences
0302 clinical medicine
Humans
Arterial Pressure
Chemistry
Altitude
Public Health, Environmental and Occupational Health
General Medicine
Effects of high altitude on humans
Oxygen
stomatognathic diseases
Breath Tests
030228 respiratory system
Exhalation
Environmental chemistry
Exhaled nitric oxide
Female
Subjects
Details
- ISSN :
- 15578682 and 15270297
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- High Altitude Medicine & Biology
- Accession number :
- edsair.doi.dedup.....bf8b2a5a18a37098f766a97893f5d104