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Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis
- Source :
- Leukemia
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group, 2019.
-
Abstract
- Precursor-B cell acute lymphoblastic leukemia (pre-B ALL) is the most common pediatric cancer, but there are no useful zebrafish pre-B ALL models. We describe the first highly- penetrant zebrafish pre-B ALL, driven by human MYC. Leukemias express B lymphoblast-specific genes and are distinct from T cell ALL (T-ALL)—which these fish also develop. Zebrafish pre-B ALL shares in vivo features and expression profiles with human pre-B ALL, and these profiles differ from zebrafish T-ALL or normal B and T cells. These animals also exhibit aberrant lymphocyte development. As the only robust zebrafish pre-B ALL model and only example where T-ALL also develops, this model can reveal differences between MYC-driven pre-B vs. T-ALL and be exploited to discover novel pre-B ALL therapies.
- Subjects :
- 0301 basic medicine
Cancer Research
Lymphocyte
Cell
Genetically Modified
Biology
medicine.disease_cause
Cell Transformation
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Article
Animals, Genetically Modified
Neoplasms, Multiple Primary
Proto-Oncogene Proteins c-myc
03 medical and health sciences
0302 clinical medicine
Multiple Primary
Neoplasms
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
medicine
Animals
Humans
Lymphopoiesis
Zebrafish
Regulation of gene expression
Neoplastic
Gene Expression Profiling
Hematology
biology.organism_classification
Pediatric cancer
3. Good health
Gene Expression Regulation, Neoplastic
Gene expression profiling
Cell Transformation, Neoplastic
030104 developmental biology
medicine.anatomical_structure
Oncology
Gene Expression Regulation
030220 oncology & carcinogenesis
Cancer research
Carcinogenesis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Leukemia
- Accession number :
- edsair.doi.dedup.....bf89c207504a34734639f46d27a490a0