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Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors
- Source :
- Current Neuropharmacology. 19:1323-1344
- Publication Year :
- 2021
- Publisher :
- Bentham Science Publishers Ltd., 2021.
-
Abstract
- The aim of this work is to review tacrine analogues from the last three years, which were not included in the latest review work, donepezil and galantamine hybrids from 2015 and rivastigmine derivatives from 2014. In this account, we summarize the efforts toward the development and characterization of non-toxic inhibitors of cholinesterases based on mentioned drugs with various interesting additional properties such as antioxidant, decreasing β-amyloid plaque aggregation, nitric oxide production, pro-inflammatory cytokines release, monoamine oxidase-B activity, cytotoxicity and oxidative stress in vitro and in animal model that classify these hybrids as potential multifunctional therapeutic agents for Alzheimer’s disease. Moreover, herein, we have described the cholinergic hypothesis, mechanisms of neurodegeneration and current pharmacotherapy of Alzheimer’s disease based on the restoration of cholinergic function through blocking enzymes that break down acetylcholine.
- Subjects :
- Monoamine oxidase
Rivastigmine
Pharmacology
Alzheimer Disease
medicine
Galantamine
Animals
Donepezil
Pharmacology (medical)
Cholinesterase
biology
business.industry
Neurodegeneration
General Medicine
medicine.disease
Psychiatry and Mental health
Neurology
Tacrine
biology.protein
Cholinergic
Cholinesterase Inhibitors
Neurology (clinical)
business
medicine.drug
Subjects
Details
- ISSN :
- 1570159X
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Current Neuropharmacology
- Accession number :
- edsair.doi.dedup.....bf7ec7d50aae0b3189960a717fb7638d