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Comparative evaluation of magnetic hyperthermia performance and biocompatibility of magnetite and novel Fe-doped hardystonite nanoparticles for potential bone cancer therapy
- Source :
- Materials scienceengineering. C, Materials for biological applications. 98
- Publication Year :
- 2018
-
Abstract
- Hyperthermia-increasing temperature of cancerous tissue for a short period of time-is considered as an effective treatment for various cancer types such as malignant bone tumors. Superparamagnetic and ferromagnetic particles have been studied for their hyperthermic properties in treating various types of cancers. The activation of magnetic nanoparticles by an alternating magnetic field is currently being explored as a technique for targeted therapeutic heating of different tumors and is being studied as an adjuvant to conventional chemotherapy and radiation therapy. In the case of bone cancers, to increase the efficiency of treatment in the hyperthermia therapy, employed materials should support bone regeneration as well. Magnetite is one of the most attractive magnetic nanoceramics used in hyperthermia application. However, biocompatibility and bioactivity of this material have raised questions. There is a high demand for extremely efficient hyperthermia materials which are equally biocompatible to non-tumor cells and tissues. We report the development of a biocompatible and bioactive material with desirable magnetic properties that show excellent hyperthermia properties and can be used for destruction of the cancerous tissue in addition to supporting tissue regeneration for treatment of bone tumors. In the current study, iron (Fe3+)-containing HT nanostructured material was prepared, and its biocompatibility, bioactivity, and hyperthermia abilities were studied. The developed materials showed effective hyperthermic properties with increased biocompatibility as compared to magnetite.
- Subjects :
- Hyperthermia
Materials science
Biocompatibility
medicine.medical_treatment
Iron
Bioengineering
Bone Neoplasms
02 engineering and technology
010402 general chemistry
01 natural sciences
Biomaterials
Magnetics
X-Ray Diffraction
Cell Line, Tumor
medicine
Humans
Bone regeneration
Magnetite Nanoparticles
Cell Proliferation
Bone cancer
Silicates
Mesenchymal Stem Cells
Hyperthermia, Induced
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
medicine.disease
Hyperthermia therapy
Dynamic Light Scattering
0104 chemical sciences
Hardystonite
Magnetic hyperthermia
Mechanics of Materials
Magnetic nanoparticles
Powders
0210 nano-technology
Biomedical engineering
Subjects
Details
- ISSN :
- 18730191
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Materials scienceengineering. C, Materials for biological applications
- Accession number :
- edsair.doi.dedup.....bf7db8167fc1612bc606ba0629311034