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Long-term clinical outcomes of papillary thyroid carcinoma patients with biochemical incomplete response
- Source :
- Endocrine. 67(3)
- Publication Year :
- 2019
-
Abstract
- The aim of this study was to evaluate the long-term clinical outcomes of papillary thyroid carcinoma (PTC) patients exhibiting biochemical incomplete response (BIR) to initial therapy. We evaluated 102 patients with PTC showing a BIR during the first 12–24 months after total thyroidectomy and radioactive iodine therapy. Patients were divided into three groups according to changes in stimulated thyroglobulin (Tg) and anti-Tg antibody (TgAb) levels: the increasing TgAb group (n = 19, 18.6%), the decreasing Tg group (n = 58, 56.9%), and the increasing Tg group (n = 25, 24.5%). With a median follow-up of 12 years, 43 (42%) patients had structural persistent disease as follows: 36 (84%) at regional sites and 7 (16%) at distant sites. The rate of structural persistent disease was significantly different between groups, with 21%, 41%, and 60% in the increasing TgAb, decreasing Tg, and increasing Tg groups, respectively (P = 0.012). Among patients without structural persistent disease, only 19 (18.6%) showed no evidence of disease and 40 (39.2%) were of a biochemical persistent status at the time of final follow-up. Increasing Tg after initial therapy was a significant risk factor for structural persistent disease in patients with BIR (HR, 4.16; 95% confidence interval (CI): 1.38–12.54, P = 0.011). PTC patients with BIR showed a high rate of structural persistent disease and Tg change after initial therapy is the most important prognostic factor for determining clinical outcomes of these patients.
- Subjects :
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
030209 endocrinology & metabolism
Disease
Gastroenterology
Thyroglobulin
Thyroid carcinoma
Iodine Radioisotopes
03 medical and health sciences
0302 clinical medicine
Endocrinology
Internal medicine
Diabetes mellitus
medicine
Humans
In patient
Thyroid Neoplasms
Retrospective Studies
Total thyroidectomy
biology
business.industry
medicine.disease
Confidence interval
Carcinoma, Papillary
Thyroid Cancer, Papillary
030220 oncology & carcinogenesis
biology.protein
Thyroidectomy
Antibody
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 15590100
- Volume :
- 67
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Endocrine
- Accession number :
- edsair.doi.dedup.....bf69f1fa75616ba6c7baefd307d2b996