Back to Search
Start Over
Utility of Magnetic Resonance Spectroscopy for the Progression of Neurological Symptoms in Lenticulostriate Artery Territory Infarction
- Source :
- Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 30(6)
- Publication Year :
- 2021
-
Abstract
- Objectives The present study aimed to examine the effectiveness of proton magnetic resonance spectroscopy (1HMRS) in determining the progression of neurological symptoms resulting in acute ischemic stroke in patients with lenticulostriate artery (LSA) infarction. Materials and Methods 1HMRS was performed within 72 h after neurological symptom onset. Voxel of interest was placed in tissue that included the pyramidal tract and identified diffusion weighted echo planar spin-echo sequence (DWI) coronal images. Infarct volume in DWI was calculated using the ABC/2 method. 1HMRS data (tNAA, tCr, Glx, tCho, and Ins) were analyzed using LCModel. Progressive neurological symptoms were defined as an increase of 1 or more in the NIHSS score. Patients who underwent 1HMRS after progressive neurological symptoms were excluded. Results In total, 77 patients were enrolled. Of these, 19 patients had progressive neurological symptoms. The patients with progressive neurological symptoms were significantly more likely to be female and had higher tCho/tCr values, higher rates of axial slices ≥ 3 slices on DWI, higher infarct volume on DWI, higher maximum diameter of infarction of axial slice on DWI, and higher SBP on admission compared to those without. Multivariable logistic analysis revealed that higher tCho/tCr values were independently associated with progressive neurological symptoms after adjusting for age, sex, and initial DWI infarct volume (tCho/tCr per 0.01 increase, OR 1.26, 95% CI 1.03–1.52, P = 0.022). Conclusions Increased tCho/tCr score were associated with progressive neurological symptoms in patients with LSA ischemic stroke. Quantitative evaluation of 1HMRS parameters may be useful for predicting the progression of neurological symptoms.
- Subjects :
- Brain Infarction
Male
medicine.medical_specialty
Proton Magnetic Resonance Spectroscopy
Infarction
Lenticulostriate artery
Choline
03 medical and health sciences
Disability Evaluation
0302 clinical medicine
Predictive Value of Tests
Internal medicine
medicine
Humans
In patient
cardiovascular diseases
Aged
Aged, 80 and over
Pyramidal tracts
business.industry
Basal Ganglia Cerebrovascular Disease
Rehabilitation
Middle Aged
medicine.disease
Creatine
medicine.anatomical_structure
Diffusion Magnetic Resonance Imaging
Coronal plane
Ischemic stroke
Logistic analysis
Infarct volume
Cardiology
Disease Progression
Surgery
Female
Neurology (clinical)
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- ISSN :
- 15328511
- Volume :
- 30
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
- Accession number :
- edsair.doi.dedup.....bf5f7e9e684fd2f2830cb4d72c66b387