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Profiling by image registration reveals common origin of annelid mushroom bodies and vertebrate pallium
- Source :
- Cell. 142(5)
- Publication Year :
- 2010
-
Abstract
- SummaryThe evolution of the highest-order human brain center, the “pallium” or “cortex,” remains enigmatic. To elucidate its origins, we set out to identify related brain parts in phylogenetically distant animals, to then unravel common aspects in cellular composition and molecular architecture. Here, we compare vertebrate pallium development to that of the mushroom bodies, sensory-associative brain centers, in an annelid. Using a newly developed protocol for cellular profiling by image registration (PrImR), we obtain a high-resolution gene expression map for the developing annelid brain. Comparison to the vertebrate pallium reveals that the annelid mushroom bodies develop from similar molecular coordinates within a conserved overall molecular brain topology and that their development involves conserved patterning mechanisms and produces conserved neuron types that existed already in the protostome-deuterostome ancestors. These data indicate deep homology of pallium and mushroom bodies and date back the origin of higher brain centers to prebilaterian times.
- Subjects :
- EVO_ECOL
animal structures
DEVBIO
General Biochemistry, Genetics and Molecular Biology
MOLNEURO
biology.animal
medicine
Animals
Humans
Deep homology
Mushroom Bodies
Body Patterning
Cerebral Cortex
Annelid
biology
Biochemistry, Genetics and Molecular Biology(all)
Brain Part
Vertebrate
Polychaeta
Anatomy
Human brain
biology.organism_classification
Biological Evolution
medicine.anatomical_structure
Evolutionary biology
Cerebral cortex
Mushroom bodies
Vertebrates
Platynereis
Subjects
Details
- ISSN :
- 10974172
- Volume :
- 142
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....bf551f69e2410b7bdaace27bb1c8773c