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The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells
- Source :
- Immunity, Immunity, 2013, 39 (6), pp.1132-42. ⟨10.1016/j.immuni.2013.11.002⟩, Immunity, Elsevier, 2013, 39 (6), pp.1132-42. ⟨10.1016/j.immuni.2013.11.002⟩, Immunity, Elsevier, 2013, 39 (6), pp.1132-42. 〈10.1016/j.immuni.2013.11.002〉, Bioessays
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- International audience; HIV-2 is less pathogenic for humans than HIV-1 and might provide partial cross-protection from HIV-1-induced pathology. Although both viruses replicate in the T cells of infected patients, only HIV-2 replicates efficiently in dendritic cells (DCs) and activates innate immune pathways. How HIV is sensed in DC is unknown. Capsid-mutated HIV-2 revealed that sensing by the host requires viral cDNA synthesis, but not nuclear entry or genome integration. The HIV-1 capsid prevented viral cDNA sensing up to integration, allowing the virus to escape innate recognition. In contrast, DCs sensed capsid-mutated HIV-1 and enhanced stimulation of T cells in the absence of productive infection. Finally, we found that DC sensing of HIV-1 and HIV-2 required the DNA sensor cGAS. Thus, the HIV capsid is a determinant of innate sensing of the viral cDNA by cGAS in dendritic cells. This pathway might potentially be harnessed to develop effective vaccines against HIV-1.
- Subjects :
- MESH : DNA, Complementary
viruses
HIV Infections
MESH : Models, Biological
Genome
MESH: HIV-1
chemistry.chemical_compound
0302 clinical medicine
MESH: HIV-2
Immunology and Allergy
MESH: Nucleotidyltransferases
MESH: Capsid
MESH : DNA, Viral
Cells, Cultured
MESH : Nucleotidyltransferases
0303 health sciences
MESH: Dendritic Cells
virus diseases
MESH: HIV Infections
MESH : Immunity, Innate
Nucleotidyltransferases
3. Good health
Infectious Diseases
Capsid
030220 oncology & carcinogenesis
MESH: Immunity, Innate
MESH : Capsid
MESH : HIV-2
MESH : HIV-1
MESH: Cells, Cultured
DNA, Complementary
CypA
Immunology
innate antiviral immunity
chemical and pharmacologic phenomena
Biology
Models, Biological
Virus
03 medical and health sciences
Immune system
Immunity
Complementary DNA
MESH : Cells, Cultured
[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology
MESH : HIV Infections
Humans
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology
030304 developmental biology
Innate immune system
MESH: Humans
HIV-1 capsid
MESH : Humans
MESH: Models, Biological
Dendritic Cells
MESH: DNA, Complementary
biochemical phenomena, metabolism, and nutrition
Virology
Immunity, Innate
MESH: DNA, Viral
Prospects & Overviews
chemistry
MESH : Dendritic Cells
DNA, Viral
HIV-2
HIV-1
cytosolic DNA sensor
DNA
cGAS
Subjects
Details
- Language :
- English
- ISSN :
- 10747613
- Database :
- OpenAIRE
- Journal :
- Immunity, Immunity, 2013, 39 (6), pp.1132-42. ⟨10.1016/j.immuni.2013.11.002⟩, Immunity, Elsevier, 2013, 39 (6), pp.1132-42. ⟨10.1016/j.immuni.2013.11.002⟩, Immunity, Elsevier, 2013, 39 (6), pp.1132-42. 〈10.1016/j.immuni.2013.11.002〉, Bioessays
- Accession number :
- edsair.doi.dedup.....bf53bdd8d5bdf7db495b8c270aebb668