Back to Search
Start Over
LEAP-2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study
- Source :
- Iubmb Life
- Publication Year :
- 2021
- Publisher :
- WILEY, 2021.
-
Abstract
- Ghrelin and its endogenous antagonist liver‐expressed antimicrobial peptide‐2 (LEAP‐2) are involved in GH secretion and glucose/lipids metabolism. LEAP‐2 expression in conditions of metabolic impairment may be upregulated, usually pairing with a concomitant reduction in ghrelin secretion. Adult growth hormone deficiency (aGHD) is characterized by insulin resistance, weight gain, and increased fat mass. Therefore, the primary endpoint of this cross‐sectional observational pilot study was to compare circulating LEAP‐2 and ghrelin levels in aGHD and healthy controls. Thirty patients were included in the study. Group A included adult GHD: 15 patients, 8 females, and 7 males. Median and interquartile range age of the group was 53 (41–57) years, while BMI was 27.1 (25–35) kg/m2. Group B was formed by 15 healthy controls (10 females and 5 males). Median and interquartile range age was 47 (36–57) years, while BMI 22.9 (20.8–33.1) kg/m2. They were evaluated for serum glucose and insulin, HOMA‐index, QUICKI‐index, total/LDL/HDL cholesterol, triglycerides, IGF‐1, ghrelin, and LEAP‐2. Ghrelin levels in the aGHD group were significantly lower than in healthy controls. In contrast, LEAP‐2 showed a trend toward higher levels, although the differences were not significant. However, the LEAP‐2/Ghrelin ratio was significantly higher in aGHD. No significant correlations between ghrelin and LEAP‐2 with BMI and HOMA index were found in aGHD population. However, a significant inverse correlation (r 2 = 0.15, p = .047) between BMI and ghrelin was evidenced when considering the whole population. Taken together, these results may suggest a body adaptation to a metabolic scenario typical of aGHD. The decrease in ghrelin production could prevent further weight gain and fat mass increase, although losing its secretagogue effect.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_treatment
Clinical Biochemistry
Pilot Projects
Biochemistry
Research Communications
Body Mass Index
0302 clinical medicine
Interquartile range
insulin resistance
education.field_of_study
Human Growth Hormone
LEAP-2
LEAP‐2
Blood Proteins
Middle Aged
Growth hormone secretion
030220 oncology & carcinogenesis
ghrelin
Ghrelin
Female
medicine.symptom
Ghrelin secretion
Adult
medicine.medical_specialty
Settore BIO/14 - FARMACOLOGIA
Population
03 medical and health sciences
Research Communication
Insulin resistance
Internal medicine
Genetics
medicine
Humans
education
Molecular Biology
business.industry
Insulin
biomarkers
Settore MED/13 - ENDOCRINOLOGIA
Cell Biology
medicine.disease
030104 developmental biology
Endocrinology
Cross-Sectional Studies
Case-Control Studies
business
Weight gain
GHD
Antimicrobial Cationic Peptides
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Iubmb Life
- Accession number :
- edsair.doi.dedup.....bf40564e35bd54f606f6d2ae8394759b