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SARS-CoV-2-Encoded Proteome and Human Genetics: From Interaction-Based to Ribosomal Biology Impact on Disease and Risk Processes
- Source :
- Journal of Proteome Research
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- SARS-CoV-2 (COVID-19) has infected millions of people worldwide, with lethality in hundreds of thousands. The rapid publication of information, both regarding the clinical course and the viral biology, has yielded incredible knowledge of the virus. In this review, we address the insights gained for the SARS-CoV-2 proteome, which we have integrated into the Viral Integrated Structural Evolution Dynamic Database, a publicly available resource. Integrating evolutionary, structural, and interaction data with human proteins, we present how the SARS-CoV-2 proteome interacts with human disorders and risk factors ranging from cytokine storm, hyperferritinemic septic, coagulopathic, cardiac, immune, and rare disease-based genetics. The most noteworthy human genetic potential of SARS-CoV-2 is that of the nucleocapsid protein, where it is known to contribute to the inhibition of the biological process known as nonsense-mediated decay. This inhibition has the potential to not only regulate about 10% of all biological transcripts through altered ribosomal biology but also associate with viral-induced genetics, where suppressed human variants are activated to drive dominant, negative outcomes within cells. As we understand more of the dynamic and complex biological pathways that the proteome of SARS-CoV-2 utilizes for entry into cells, for replication, and for release from human cells, we can understand more risk factors for severe/lethal outcomes in patients and novel pharmaceutical interventions that may mitigate future pandemics.
- Subjects :
- nonsense-mediated decay
0301 basic medicine
Proteome
viruses
Pneumonia, Viral
Nonsense-mediated decay
nucleocapsid
Reviews
viral-induced genetics
Disease
Computational biology
Biology
Proteomics
Biochemistry
Virus
Transcriptome
transcriptomics
Betacoronavirus
Viral Proteins
03 medical and health sciences
proteomics
Databases, Genetic
medicine
risk factors
Humans
Pandemics
host interactions
030102 biochemistry & molecular biology
SARS-CoV-2
Gene Expression Profiling
COVID-19
General Chemistry
medicine.disease
Human genetics
030104 developmental biology
Host-Pathogen Interactions
Coronavirus Infections
Cytokine storm
Ribosomes
Subjects
Details
- ISSN :
- 15353907 and 15353893
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Journal of Proteome Research
- Accession number :
- edsair.doi.dedup.....bf2ebf723e982abc121b87ab99039b9f