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Severity of Non-B and Non-C Hepatitis Versus Hepatitis B and C Associated Chronic Liver Disease: A Retrospective, Observational, Comparative Study
- Source :
- Cureus
- Publication Year :
- 2021
-
Abstract
- Background and objectives Chronic liver disease (CLD) encompasses a variety of etiologies, and the infectious causes are mainly hepatitis B and hepatitis C virus. Chronic alcohol abuse and non-alcoholic fatty liver disease also have a major contribution to CLD. The Child-Pugh scoring system indicates the probable prognosis and mortality risk of a patient with cirrhosis. The primary objective of this research is to observe the mortality risks of CLD caused by a variety of etiologies mentioned above. The secondary objective is to determine the biochemical markers that are correlating with the severity of the study groups. Another aim was to determine the Model for End-Stage Liver Disease (MELD) scoring of each study group predicting the severity of disease among the Child-Pugh classification. Materials and methods We broadly classified the etiologies into two study groups: (1) hepatitis B, C associated CLD (hepatitis B, C--CLD) and (2) non-hepatitis B, C associated CLD (non-hepatitis B, C-CLD). This study was conducted as a descriptive, retrospective study involving patients admitted to the Gastroenterology Department at Dow University Hospital between July 2019 and December 2019. All patients who met the inclusion criteria were included in the study in order to document their levels of severity markers of CLD. A total of 167 individuals met the inclusion criteria, and the sampling was done through non-probability consecutive methods. All continuous variables were described as mean and standard deviations, which were then compared using an independent sample t-test. The comparison of categorical data was done either using the chi-square test or Fisher's exact test accordingly. A p-value of
- Subjects :
- medicine.medical_specialty
congenital, hereditary, and neonatal diseases and abnormalities
Cirrhosis
Hepatitis C virus
Infectious Disease
030204 cardiovascular system & hematology
Chronic liver disease
medicine.disease_cause
Gastroenterology
hepatitis c infection
03 medical and health sciences
Liver disease
severity markers
0302 clinical medicine
Internal medicine
medicine
Internal Medicine
child-pugh class
meld
liver fibrosis
Hepatitis
business.industry
cirrhosis
Fatty liver
hepatitis b infection
General Engineering
chronic liver disease
Hepatitis B
respiratory system
nonalcoholic fatty liver disease (nafld)
medicine.disease
respiratory tract diseases
chronic viral hepatitis
Population study
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 21688184
- Volume :
- 12
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Cureus
- Accession number :
- edsair.doi.dedup.....bf28746ccee3b393e013f5e812ac8f3b