New benzopyrans: Anticonvulsant activities

Three new analogs of dimethylheptylpyran (DMHP) (SP-141, SP-143, and SP-175) were found to exhibit significant anticonvulsant activity against audiogenic, supramaximal electroshock, and maximal pentylentetrazol induced seizures in mice. In rats, all three compounds were found to be more active than diphenylhydantoin in the supramaximal electroshock test. In particular, a different profile of anticonvulsant activity was demonstrated for SP-175 compared to DMHP or delta-9-THC. It was discovered in 5-day studies that dilantin, phenobarbital, DMHP, and SP-175 do not exhibit tolerance development against audiogenic seizures in mice.