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Anti-hnRNP B1 (RA33) Autoantibodies Are Associated with the Clinical Phenotype in Russian Patients with Rheumatoid Arthritis and Systemic Sclerosis
- Source :
- Journal of Immunology Research, Journal of Immunology Research, Vol 2014 (2014)
- Publication Year :
- 2014
- Publisher :
- Hindawi Publishing Corporation, 2014.
-
Abstract
- Heterogeneous nuclear ribonucleoproteins (hnRNPs) are potent autoantigenic targets in systemic autoimmune rheumatic diseases (SARD). Loss of tolerance to the RA33 complex consisting of hnRNP A2 and its alternatively spliced variants B1 and B2 has been the interest of rheumatologists. A novel ELISA for the detection of anti-hnRNP B1 autoantibodies has been developed to investigate the prevalence thereof in 397 patients with SARD, including patients with rheumatoid arthritis (RA), spondyloarthropathy (SPA), juvenile chronic arthritis, systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and Sjögren’s syndrome (SS), in comparison to 174 controls. Anti-hnRNP B1 autoantibodies were significantly more prevalent in patients with SARD than controls (47/397, 11.8% versus 2/174, 1.1%;P<0.001). In particular, anti-hnRNP B1 were found more frequently in the disease cohorts than in the controls and were present in 24/165 (14.5%) patients with RA, 6/58 (10.3%) SPA, 11/65 (16.9%) SSc, and 4/50 (8.0%) SLE. In RA patients, anti-hnRNP B1 autoantibodies correlated significantly with C-reactive protein levels and erythrocyte sedimentation rate, while in patients with SSc it was associated with features of arterial wall stiffness and presence of hypertension. Anti-hnRNP B1 autoantibodies occur in SARD and seem to be correlated with distinct clinical characteristics in patients with RA and SSc.
- Subjects :
- lcsh:Immunologic diseases. Allergy
Adult
Male
Adolescent
Article Subject
Spondyloarthropathy
Immunology
Arthritis
Enzyme-Linked Immunosorbent Assay
Blood Sedimentation
Autoantigens
Russia
Arthritis, Rheumatoid
Vascular Stiffness
Heterogeneous-Nuclear Ribonucleoprotein Group A-B
medicine
Humans
Lupus Erythematosus, Systemic
Immunology and Allergy
Child
skin and connective tissue diseases
Autoantibodies
Scleroderma, Systemic
Lupus erythematosus
medicine.diagnostic_test
business.industry
Autoantibody
General Medicine
Middle Aged
medicine.disease
Arthritis, Juvenile
C-Reactive Protein
Sjogren's Syndrome
Case-Control Studies
Erythrocyte sedimentation rate
Rheumatoid arthritis
Hypertension
Spondylarthropathies
Female
RA33
lcsh:RC581-607
business
Research Article
Anti-SSA/Ro autoantibodies
Subjects
Details
- Language :
- English
- ISSN :
- 23148861
- Database :
- OpenAIRE
- Journal :
- Journal of Immunology Research
- Accession number :
- edsair.doi.dedup.....bf17a381dc1f7ff13e9b056ccdd73d62
- Full Text :
- https://doi.org/10.1155/2014/516593