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Subkutane Fett Topographie und metabolische Störungen beim Polyzystischen Ovar Syndrom
- Source :
- Wiener klinische Wochenschrift. 121:262-269
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- OBJECTIVE: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. Central obesity plays a major role in the pathophysiology of PCOS. However, there is little information on the impact of subcutaneous adipose tissue (SAT) on metabolic disturbances in PCOS. The aim of this study was to investigate whether SAT topography influences insulin resistance, impaired glucose tolerance and metabolic parameters in women with PCOS. METHODS: 36 women aged 16–41 years with PCOS and 87 healthy women aged 20–34 years were examined using lipometry, metabolic and hormonal measurements, oral glucose tolerance tests, hirsutism scores, and questionnaires. The homeostasis model assessment (HOMA) index was used for determination of insulin resistance. RESULTS: SAT measurement points on the trunk showed significant positive correlation with the HOMA index. A negative correlation between calf SAT and the HOMA index was seen. Multiple regression analysis detected a positive association between the HOMA index and lower-abdomen SAT and upper-back SAT, whereas hip SAT showed a negative association with the HOMA index. In overweight/obese patients with PCOS, lower-abdomen and upper-back SAT showed significant positive correlations with insulin resistance. There was no correlation of SAT topography with insulin resistance in lean women with PCOS. Compared with PCOS women with normal glucose tolerance, patients with glucose intolerance had significantly increased trunk obesity and decreased leg fat. Increased SAT layers on the trunk were related to an unfavorable serum lipid profile, whereas increased leg fat correlated positively with HDL cholesterol. CONCLUSIONS: Increased SAT layers on the trunk are associated with insulin resistance, impaired glucose tolerance and an unfavorable lipid profile in women suffering from PCOS. Increased thickness of leg SAT emerges as being protective against metabolic disturbances in PCOS.
- Subjects :
- Adult
Blood Glucose
medicine.medical_specialty
Adolescent
endocrine system diseases
Statistics as Topic
Adipose tissue
Overweight
Body Mass Index
Impaired glucose tolerance
Young Adult
Waist–hip ratio
Insulin resistance
Risk Factors
Internal medicine
medicine
Body Fat Distribution
Humans
Metabolic Syndrome
medicine.diagnostic_test
Waist-Hip Ratio
business.industry
nutritional and metabolic diseases
General Medicine
medicine.disease
Lipids
Polycystic ovary
Subcutaneous Fat, Abdominal
Skinfold Thickness
Endocrinology
Body Composition
Female
Insulin Resistance
medicine.symptom
Lipid profile
business
Body mass index
Polycystic Ovary Syndrome
Subjects
Details
- ISSN :
- 16137671 and 00435325
- Volume :
- 121
- Database :
- OpenAIRE
- Journal :
- Wiener klinische Wochenschrift
- Accession number :
- edsair.doi.dedup.....bf0f35aad0eff6fe1a6179b647806ceb