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Evaluation of the 24-hour profiles of physiological insulin, glucose, and C-peptide in healthy Japanese volunteers
- Source :
- Diabetes technologytherapeutics. 11(8)
- Publication Year :
- 2009
-
Abstract
- Some studies have demonstrated the benefit of blood glucose control as close as possible to physiological conditions. Not enough reports have investigated in detail the 24-h plasma profiles of insulin/glucose/C-peptide. Here we investigated the 24-h plasma profiles of physiological insulin/glucose/C-peptide in healthy Japanese adults.In order to evaluate the 24-h profiles of physiological insulin/glucose/C-peptide profiles, 42 blood samples were taken from each subject in our group of healthy Japanese volunteers to measure the 24-h profile with three standardized meals.Plasma glucose and insulin increased rapidly followed by a rapid decrease after each meal with little variation at night. The average peak values of insulin after each meal were as follows: 426.20 pmol/L (breakfast), 373.75 pmol/L (lunch), and 410.28 pmol/L (dinner). The average times to peak insulin were 0.651 h (breakfast), 0.677 h (lunch), and 0.689 h (dinner). The corresponding average maximum postprandial plasma glucose levels were 8.39 mmol/L (breakfast), 8.77 mmol/L (lunch), and 8.74 mmol/L (dinner). The average times to peak glucose were 0.738 h (breakfast), 0.650 h (lunch), and 0.625 h (dinner). The average maximum postprandial C-peptide levels were 2.64 nmol/L (breakfast), 2.55 nmol/L (lunch), and 2.67 nmol/L (dinner). No major differences were found in these parameters between the Caucasian and Japanese populations.This is the first investigation to measure the 24-h profiles of insulin/glucose/C-peptide in healthy Japanese volunteers with standardized meals. It is hoped this information will provide useful reference for future research and clinical management.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Glucose control
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Blood Pressure
Body Mass Index
chemistry.chemical_compound
Eating
Young Adult
Endocrinology
Reference Values
Internal medicine
Diabetes mellitus
medicine
Humans
Insulin
Pulse
Meal
Plasma glucose
Glucose tolerance test
medicine.diagnostic_test
C-Peptide
C-peptide
business.industry
Patient Selection
digestive, oral, and skin physiology
Glucose Tolerance Test
medicine.disease
Postprandial Period
Medical Laboratory Technology
Blood pressure
chemistry
business
Subjects
Details
- ISSN :
- 15578593
- Volume :
- 11
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Diabetes technologytherapeutics
- Accession number :
- edsair.doi.dedup.....bf0b322a87346a5682b6a4cb877880ea