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Effect of high-volume hemofiltration on children with sepsis
- Source :
- Transl Pediatr
- Publication Year :
- 2020
- Publisher :
- AME Publishing Company, 2020.
-
Abstract
- BACKGROUND: Sepsis has always been a challenge in pediatric intensive care unit (PICU) with poor prognosis. In order to evaluate the effect between routine continuous renal replacement therapy (CRRT) and high-volume hemofiltration (HVHF) in children with sepsis, we performed out this prospective, randomized, controlled, open-label trial. METHODS: Forty-seven children with sepsis were enrolled from January 2015 to December 2016. Twenty-two patients in Control group received routine CRRT and 25 patients in HVHF group received HVHF within 6 hours after the diagnosis of sepsis. The oxygenation index, serum creatinine, urea, lactate, inflammatory cytokines (IL-6, IL-10, and TNF-α), pediatric risk of mortality III (PRISM III) and 28-day mortality rate were collected and compared. RESULTS: The oxygenation index in HVHF group and Control group was significantly increased at 48 hours (P0.05). CONCLUSIONS: HVHF might be an effective treatment for children with sepsis.
- Subjects :
- Pediatric intensive care unit
Creatinine
Oxygenation index
business.industry
medicine.medical_treatment
Mortality rate
030208 emergency & critical care medicine
medicine.disease
Sepsis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
chemistry
Anesthesia
Pediatrics, Perinatology and Child Health
Hemofiltration
Risk of mortality
medicine
Original Article
030212 general & internal medicine
Renal replacement therapy
business
Subjects
Details
- ISSN :
- 22244344 and 22244336
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Translational Pediatrics
- Accession number :
- edsair.doi.dedup.....bf06c1ff52b5e202332aae7056499a57