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In VivoStudies on Progesterone Metabolism by Human Skin
- Source :
- The Journal of Clinical Endocrinology & Metabolism. 29:1580-1585
- Publication Year :
- 1969
- Publisher :
- The Endocrine Society, 1969.
-
Abstract
- The metabolism of radioactive progesterone administered simultaneously intravenously and percutaneously has been studied in 4 normal subjects and 1 patient with testicular feminization syndrome. The relative contribution to urinary 5β- and 5α-pregnan-3α,20α-diol (pregnanediol and allopregnanediol) of labeled progesterone, according to its mode of administration, was determined. In normal subjects, the yield of pregnanediol originating from an intravenous dose of progesterone was 8 times higher than that of allopregnanediol. By contrast, when progesterone was administered percutaneously, the recovery of labeled allopregnanediol in urine was greater than that of pregnanediol. These data indicate that in normal subjects progesterone might be 5α-hydrogenated to a greater extent in the skin. In addition, the metabolism of progesterone administered either intravenously or percutaneously was similar in men and women; it was unchanged throughout the menstrual cycle and by estrogen treatment of men. In th...
- Subjects :
- Male
endocrine system
medicine.medical_specialty
Chromatography, Paper
Metabolic Clearance Rate
medicine.drug_class
Endocrinology, Diabetes and Metabolism
media_common.quotation_subject
Urinary system
Clinical Biochemistry
Disorders of Sex Development
Diethylstilbestrol
Urine
Tritium
Biochemistry
chemistry.chemical_compound
Endocrinology
Internal medicine
medicine
Humans
Progesterone
Testosterone
Menstrual cycle
Skin
media_common
Testicular feminization
Carbon Isotopes
Chromatography
Biochemistry (medical)
Androgen-Insensitivity Syndrome
Menstruation
chemistry
Estrogen
Pregnanediol
Female
Chromatography, Thin Layer
Crystallization
Protein Binding
medicine.drug
Subjects
Details
- ISSN :
- 19457197 and 0021972X
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....befcc9685299e1635e6e7269a39897a7