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Disseminated intravascular coagulation (DIC) in adult patients with acute leukaemia
- Source :
- European journal of haematology. 54(1)
- Publication Year :
- 1995
-
Abstract
- In 71 patients with acute leukaemia admitted for remission induction, disseminated intravascular coagulation (DIC) was looked for in 50 patients and diagnosed in 10 (20%). Of 10 patients with acute lymphoblastic leukaemia, 3 had DIC, and of 40 patients with acute myeloblastic leukaemia, 7 had DIC. The presence of DIC was related to bleeding manifestations within the first 2 weeks. A haemorrhagic diathesis was present in all DIC patients: 4 had minor and 6 had major bleeding, i.e. WHO grade > or = 2. In addition to blood product support, most DIC patients were treated with low doses of heparin and tranexamic acid. In all DIC patients the haemorrhagic symptoms preceded the heparin administration. Among 40 screened patients without DIC, 17 patients had minor and 3 had major haemorrhagic manifestations. Thus, the proportion of patients with major bleeding was significantly greater among the DIC patients (6/10 vs 3/40, p < 0.001). In conclusion, DIC at presentation was associated with a significantly increased risk for severe haemorrhagic complications and should be looked for in adults with acute leukaemia.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Hemorrhage
Fibrinogen
Gastroenterology
Leukocyte Count
hemic and lymphatic diseases
Acute lymphocytic leukemia
Internal medicine
medicine
Coagulopathy
Humans
Disseminated intravascular coagulation
business.industry
Hematology
General Medicine
Heparin
Disseminated Intravascular Coagulation
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Surgery
Leukemia
Leukemia, Myeloid, Acute
Female
Complication
business
Tranexamic acid
circulatory and respiratory physiology
medicine.drug
Subjects
Details
- ISSN :
- 09024441
- Volume :
- 54
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- European journal of haematology
- Accession number :
- edsair.doi.dedup.....befa1417fb123a7d07271a56579868bb