Back to Search
Start Over
Fluorinated scaffolds for antimalarial drug discovery
- Source :
- Expert Opinion on Drug Discovery. 15:705-718
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- The unique physicochemical properties and chemical diversity of organofluorine compounds have remarkably contributed for their wide utility in the area of pharmaceuticals, materials and agrochemicals. The noteworthy characteristics of fluorine include high electron affinity, lipophilicity and bioavailability, extending the half-life of the drugs. The incorporation of fluorine substituents, particularly trifluoromethyl groups, into organic molecules has led to their high potency against various diseases, including malaria. Hence, organofluorinated molecules offer valuable avenues for the design of new drug candidates against malaria.In this review, the authors discuss the importance of fluorine substituents present in the chemical compounds, and their potential applications for antimalarial drug discovery.Fluorinated molecules represent a reliable strategy to develop new antimalarial drugs. Fluorine or fluorinated groups have been identified as a promising precursor, and their presence in approximately twenty-five percent of approved drugs is notable. Selective fluorination of chemical entities has the potential to be applied not only to improve the activity profile against the malaria parasite, but could be extrapolated for favorable pharmacological applications. Hazardous reagents such as HF, F
- Subjects :
- 0303 health sciences
Halogenation
Drug discovery
Chemistry
Fluorine
Combinatorial chemistry
Malaria
Antimalarials
03 medical and health sciences
0302 clinical medicine
Drug Design
030220 oncology & carcinogenesis
Chemical diversity
Drug Discovery
Lipophilicity
Animals
Humans
Organofluorine compounds
030304 developmental biology
Subjects
Details
- ISSN :
- 1746045X and 17460441
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Expert Opinion on Drug Discovery
- Accession number :
- edsair.doi.dedup.....bef36ec33cbf09a205079a495dac3a7e