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HPV-6 molecular variants association with the development of genital warts in men: The HIM Study
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- Background Human papillomavirus type 6 (HPV-6) and HPV-11 are the etiological agents of approximately 90% of genital warts (GWs). The impact of HPV-6 genetic heterogeneity on persistence and progression to GWs remains undetermined. Methods HPV Infection in Men (HIM) Study participants who had HPV-6 genital swabs and/or GWs preceded by a viable normal genital swab were analyzed. Variants characterization was performed by polymerase chain reaction sequencing and samples classified within lineages (A, B) and sublineages (B1, B2, B3, B4, B5). Country- and age-specific analyses were conducted for individual variants; odds ratios and 95% confidence intervals for the risk of GWs according to HPV-6 variants were calculated. Results B3 variants were most prevalent. HPV-6 variants distribution differed between countries and case status. HPV-6 B1 variants prevalence was increased in GWs and genital swabs of cases compared to controls. There was difference in B1 and B3 variants detection in GW and the preceding genital swab. We observed significant association of HPV-6 B1 variants detection with GW development. Conclusions HPV-6 B1 variants are more prevalent in genital swabs that precede GW development, and confer an increased risk for GW. Further research is warranted to understand the possible involvement of B1 variants in the progression to clinically relevant lesions.
- Subjects :
- DOENÇAS DOS GENITAIS MASCULINOS
Adult
Male
0301 basic medicine
Adolescent
Genital warts
law.invention
Young Adult
03 medical and health sciences
Risk Factors
law
Major Article
Humans
Immunology and Allergy
Medicine
Sex organ
Prospective Studies
Mexico
Polymerase chain reaction
Aged
business.industry
Genetic heterogeneity
Papillomavirus Infections
HPV infection
Genetic Variation
virus diseases
Odds ratio
Middle Aged
Human papillomavirus 6
medicine.disease
United States
Confidence interval
030104 developmental biology
Infectious Diseases
Socioeconomic Factors
Condylomata Acuminata
Case-Control Studies
DNA, Viral
Immunology
Etiology
business
Brazil
Follow-Up Studies
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Database :
- OpenAIRE
- Journal :
- Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....bef0acfefc479261b6d572758b78f3d4