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Structural elucidation and antimicrobial characterization of novel diterpenoids from Fabiana densa var. ramulosa
- Publication Year :
- 2020
-
Abstract
- Novel diterpenoids were isolated from the extracts of Fabiana densa var. ramulosa and found to display a selective activity against Gram-positive bacterial strains with negligible cytotoxicity toward human keratinocytes. This study highlighted the role played by the acidic group at C18 of the tetracyclic ent-beyerene scaffold for antibacterial effects and how the length and flexibility of the alkyl chain between the two carbonyl groups are crucial factors to increase the antimicrobial activity of the molecules, supporting the development of natural products from F. densa and their derivatives for treatment of microbial infections.
- Subjects :
- Natural products
antimicrobial activity
biology
010405 organic chemistry
Chemistry
Fabiana
Gram-positive bacteria
Organic Chemistry
diterpenes
natural products
plant secondary metabolites
gram-positive bacteria
cytotoxicity
Antimicrobial
biology.organism_classification
01 natural sciences
Biochemistry
diterpene
Natural product
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Drug Discovery
Cytotoxicity
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....bed9ca5c1932555b5764a62db08f1222