Back to Search
Start Over
Polymorphisms in candidate genes for blood pressure regulation in young men with normal or elevated screening blood pressure
- Source :
- Blood pressure. 10(2)
- Publication Year :
- 2001
-
Abstract
- We have previously shown correlations between cardiovascular risk factors such as blood pressure (BP), sympathetic nervous system activity, lipids and insulin resistance in young men with elevated screening BP. In the present study we aimed to: (1) compare the genotype distribution and allele frequencies of 11 polymorphisms in seven candidate genes for BP regulation in healthy 21-year-old Caucasian men, between 18 men with normal and 67 men with high screening BP, and (2) evaluate the effect of these polymorphisms in candidate genes on casual BP, BP responses to mental stress or catecholamines and metabolic parameters including insulin sensitivity. There were no differences in genotype distributions or allele frequencies between the subjects with normal and those with high screening BP. Insulin sensitivity was significantly higher in GG homozygotes in the G-261A polymorphism at the alpha 2A-adrenergic receptor (alpha(2A)AR) locus compared to GA heterozygotes (p = 0.007). Subjects who were homozygous both GG in the G-261A polymorphism at the alpha(2A)AR locus and GlyGly in the Arg16Gly polymorphism at the beta2-adrenergic (beta2AR) receptor loci had significantly higher insulin sensitivity and lower catecholamine levels during mental stress than subjects with other genotypes. Subjects who were II homozygous at the angiotensin converting enzyme (ACE) locus and AA homozygous at the angiotensin type I receptor (AT1R) locus had lower BP and a better lipid profile than the rest of the group. Thus, in this explorative study, we report an association between insulin sensitivity and a polymorphism at the alpha(2A)AR locus. We suggest the presence of gene-gene interactions in the renin-angiotensin system and the sympathetic nervous system.
- Subjects :
- Adult
Male
medicine.medical_specialty
Candidate gene
Sympathetic Nervous System
Genotype
DNA Mutational Analysis
Locus (genetics)
Blood Pressure
Renin-Angiotensin System
Insulin resistance
Catecholamines
Gene Frequency
Internal medicine
Internal Medicine
medicine
Humans
Insulin
Mass Screening
Allele frequency
Polymorphism, Genetic
medicine.diagnostic_test
biology
business.industry
Heterozygote advantage
Angiotensin-converting enzyme
General Medicine
medicine.disease
Endocrinology
Hypertension
biology.protein
Glucose Clamp Technique
Cardiology and Cardiovascular Medicine
Lipid profile
business
Stress, Psychological
Subjects
Details
- ISSN :
- 08037051
- Volume :
- 10
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Blood pressure
- Accession number :
- edsair.doi.dedup.....bed7e494054d47a57ad82ff8f7f1583c