Back to Search
Start Over
Associations between measures of vascular structure and function and systemic circulating blood markers in humans
- Source :
- Physiological Reports
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Examination of relationships between systemic markers and functional measures of arterial structure and function may assist in determining alternative indices of vascular regulation and designing and evaluating interventions to improve arterial structure and function. Twenty young healthy individuals, 20 older healthy men, and 26 individuals with coronary artery disease (CAD), comprising a spectrum of vascular health, participated. Systemic markers of vascular structure and function included: pro‐collagen type I C‐peptide (PIP) – marker of collagen synthesis, C‐telopeptide of type I collagen (CTX) – marker of collagen degradation, endothelin‐1 (ET‐1) ‐ vasoconstrictor, and interleukin‐6 (IL‐6) – inflammatory marker. Functional measures of arterial structure and function included carotid artery distensibility and brachial artery flow‐mediated dilation (FMD). Moderate positive relationships were observed between carotid distensibility and CTX and PIP (r = 0.57, P
- Subjects :
- Cardiovascular Conditions, Disorders and Treatments
0301 basic medicine
medicine.medical_specialty
Pathology
Physiology
Immunology
030204 cardiovascular system & hematology
vascular function
Vascular health
Coronary artery disease
03 medical and health sciences
vascular structure
0302 clinical medicine
Physiology (medical)
medicine.artery
Internal medicine
medicine
Vascular structure
Blood markers
Brachial artery
Original Research
business.industry
medicine.disease
3. Good health
030104 developmental biology
Cardiology
Arterial stiffness
Vasculature
medicine.symptom
business
Type I collagen
Vasoconstriction
Subjects
Details
- ISSN :
- 2051817X
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Physiological Reports
- Accession number :
- edsair.doi.dedup.....becdc28d8aaa72431baae67904bb1754