Prognostic value of androgen receptor in triple negative breast cancer: A meta-analysis

// Changjun Wang 1, * , Bo Pan 1, * , Hanjiang Zhu 2 , Yidong Zhou 1 , Feng Mao 1 , Yan Lin 1 , Qianqian Xu 1 , Qiang Sun 1 1 Department of Breast Surgery, Peking Union Medical College Hospital, Beijing, China 2 Department of Dermatology, University of California, San Francisco, CA, USA * These authors have contributed equally to this work Correspondence to: Qiang Sun, email: sunqiangpumch@sina.com Keywords: androgen receptor, breast cancer, triple negative breast cancer, prognostic value, meta-analysis Received: April 12, 2016 Accepted: June 03, 2016 Published: June 21, 2016 ABSTRACT Background: Androgen receptor (AR) is a promising therapeutic target for breast cancer. However, its prognostic value remains controversial in triple negative breast cancer (TNBC). Here we present a meta-analysis to investigate the correlation between AR expression and TNBC prognosis. Results: Thirteen relevant studies with 2826 TNBC patients were included. AR positive rate was 24.4%. AR+ patients tended to have lower tumor grade ( p < 0.001), but more lymph node metastases ( p < 0.01). AR positivity was associated with prolonged disease free survival (HR 0.809, 95% CI = 0.659-0.995, p < 0.05), but had no significant impact on overall survival (HR 1.270, 95% CI=0.904-1.782, p = 0.168). No difference in survival existed between subgroups using different AR or estrogen receptor cutoff values. Materials and methods: Literature search was performed in Pubmed, Embase and Cochrane Central Register of Controlled Trials databases to identify relevant articles on AR and TNBC prognosis. Fixed- and random-effect meta-analyses were conducted based on the heterogeneity of included studies. Heterogeneity and impacts of covariates were further evaluated by subgroup analyses and meta-regression. Conclusion: AR positivity is associated with lower risk of disease recurrence in TNBC. Further clinical studies are warranted to clarify its prognostic role on TNBC recurrence and survival.